ArticleProceedings of the National Academy of Sciences of the United States of America2004
Painting of fourth in genus Drosophila suggests autosome-specific gene regulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed.
- RNA-binding protein Ars2 mediates transcriptional silencing of telomeric repeats and transposable elements in the Drosophila germline.Nucleic acids research · 2025Article
- Long-read genome assemblies for the study of chromosome expansion: Drosophila kikkawai, Drosophila takahashii, Drosophila bipectinata, and Drosophila ananassae.G3 (Bethesda, Md.) · 2023Article
- Long-read genome assemblies for the study of chromosome expansion:bioRxiv : the preprint server for biology · 2023Article
- The role of H3K36 methylation and associated methyltransferases in chromosome-specific gene regulation.Science advances · 2021Article
- The genomes of a monogenic fly: views of primitive sex chromosomes.Scientific reports · 2020Article
- Complex Evolutionary History of the Y Chromosome in Flies of the Drosophila obscura Species Group.Genome biology and evolution · 2020Article
- Article
- RNA-on-X 1 and 2 in Drosophila melanogaster fulfill separate functions in dosage compensation.PLoS genetics · 2018Article
- The X-linked 1.688 Satellite inGenetics · 2018Article
- Proximity ligation assays of protein and RNA interactions in the male-specific lethal complex on Drosophila melanogaster polytene chromosomes.Chromosoma · 2015Article
- Ancestral Chromatin Configuration Constrains Chromatin Evolution on Differentiating Sex Chromosomes in Drosophila.PLoS genetics · 2015Article
- Never settling down: frequent changes in sex chromosomes.PLoS biology · 2015Article
- Genome-wide mapping of Painting of fourth on Drosophila melanogaster salivary gland polytene chromosomes.Genomics data · 2014Article
- Recurrent turnover of chromosome-specific satellites in Drosophila.Genome biology and evolution · 2014Article
- Targeting of Painting of fourth to roX1 and roX2 proximal sites suggests evolutionary links between dosage compensation and the regulation of the fourth chromosome in Drosophila melanogaster.G3 (Bethesda, Md.) · 2013Article
- Article
- HP1a, Su(var)3-9, SETDB1 and POF stimulate or repress gene expression depending on genomic position, gene length and expression pattern in Drosophila melanogaster.Nucleic acids research · 2013Article
- Enrichment of HP1a on Drosophila chromosome 4 genes creates an alternate chromatin structure critical for regulation in this heterochromatic domain.PLoS genetics · 2012Article
- Buffering and proteolysis are induced by segmental monosomy in Drosophila melanogaster.Nucleic acids research · 2012Article
- POF regulates the expression of genes on the fourth chromosome in Drosophila melanogaster by binding to nascent RNA.Molecular and cellular biology · 2012Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Painting of fourth (POF) is a chromosome-specific protein in Drosophila and represents the first example of an autosome-specific protein. POF binds to chromosome 4 in Drosophila melanogaster, initiating at the proximal region, followed by a spreading dependent on chromosome 4-specific sequences or structures. Chromosome-specific gene regulation is known thus far only as a mechanism to equalize the transcriptional activity of the single male X chromosome with that of the two female X chromosomes. In Drosophila, a complex including the male-specific lethal proteins, "paints" the male X chromosome, mediating its hypertranscription, explained to some extent by the acetylation of lysine 16 on histone H4. Here, we show that Pof is essential for viability in both sexes and for female fertility. POF binding to an autosome, the F element, is conserved in genus Drosophila, indicating functional conservation of the autosome specificity. In three of nine studied species, POF binds to the male X chromosome. When bound to the male X, it also colocalizes with the dosage compensation protein male-specific lethal 3, suggesting a relationship to dosage compensation. The chromosome specificity is determined at the species level and not by the amino acid sequence. We argue that POF is involved in a chromosome-specific regulatory function.
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