ArticleProceedings of the National Academy of Sciences of the United States of America2004
Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 110 citations in OpenAlex.
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- Hearing loss and tinnitus: association studies for complex-hearing disorders in mouse and man.Human genetics · 2022Review
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- Strong conservation of inbred mouse strain microRNA loci but broad variation in brain microRNAs due to RNA editing and isomiR expression.RNA (New York, N.Y.) · 2018Article
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- Whole exome sequencing of wild-derived inbred strains of mice improves power to link phenotype and genotype.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction.G3 (Bethesda, Md.) · 2016Article
- Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture.BMC genomics · 2015Article
- The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency-Specific Genetic Determinants.G3 (Bethesda, Md.) · 2015Article
- Nutrition and the science of disease prevention: a systems approach to support metabolic health.Annals of the New York Academy of Sciences · 2015Review
- Susceptibility to Klebsiella pneumonaie infection in collaborative cross mice is a complex trait controlled by at least three loci acting at different time points.BMC genomics · 2014Article
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- The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Deconstructing Mus gemischus: advances in understanding ancestry, structure, and variation in the genome of the laboratory mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Review
- A better prognosis for genetic association studies in mice.Trends in genetics : TIG · 2012Article
- Cofilin-1: a modulator of anxiety in mice.PLoS genetics · 2012Article
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- A modifier gene alleviates hypothyroidism-induced hearing impairment in Pou1f1dw dwarf mice.Genetics · 2011Article
- Collaborative Cross mice and their power to map host susceptibility to Aspergillus fumigatus infection.Genome research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Investigation of sequence variation in common inbred mouse strains has revealed a segmented pattern in which regions of high and low variant density are intermixed. Furthermore, it has been suggested that allelic strain distribution patterns also occur in well defined blocks and consequently could be used to map quantitative trait loci (QTL) in comparisons between inbred strains. We report a detailed analysis of polymorphism distribution in multiple inbred mouse strains over a 4.8-megabase region containing a QTL influencing anxiety. Our analysis indicates that it is only partly true that the genomes of inbred strains exist as a patchwork of segments of sequence identity and difference. We show that the definition of haplotype blocks is not robust and that methods for QTL mapping may fail if they assume a simple block-like structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.