ReviewMolecular diversity2004
The rational design of an anti-caries peptide against Streptococcus mutans.
Review in Molecular diversity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Virtual Screening of Inhibitors ofACS medicinal chemistry letters · 2024Article
- The Application of Small Molecules to the Control of Typical Species Associated With Oral Infectious Diseases.Frontiers in cellular and infection microbiology · 2022Review
- Diaryl Urea Derivative Molecule Inhibits CariogenicFrontiers in cellular and infection microbiology · 2022Article
- Small Molecule Compounds, A Novel Strategy againstPathogens (Basel, Switzerland) · 2021Review
- Development and characterization of p1025-loaded bioadhesive liquid-crystalline system for the prevention ofInternational journal of nanomedicine · 2018Article
- Review
- Article
- Durable bonds at the adhesive/dentin interface: an impossible mission or simply a moving target?Brazilian dental science · 2012Article
Corrections and comments
- Commented on by
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cariogenic bacterium Streptococcus mutans attaches to tooth surfaces via a cell surface adhesin termed streptococcal antigen I/II (SA I/II). Mapping studies identified an adhesion epitope within residues 1025-1044. A synthetic peptide (p1025) spanning these residues inhibited adhesion of S. mutans in vitro and was tested in an in vivo human streptococcal adhesion model. Direct application of p1025 to the teeth prevented recolonisation of the oral cavity by S. mutans but not Actinomyces naeslundii. This review also describes various other adhesion-inhibiting peptides have been identified in vitro. We suggest that adhesion-blocking synthetic peptides may provide novel anti-infective agents. Topical application of such peptides at mucosal surfaces does not provide sustained selective pressure and in contrast to antibiotics, may not induce resistance.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.