Evidence map›Paper›PMID 15209160›Full record

ReviewMolecular diversity2004

Protein recognition using synthetic surface-targeted agents.

Rishi Jain, Justin T Ernst, Olaf Kutzki, Hyung Soon Park, Andrew D Hamilton

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular diversity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Synthesis of the phenylpyridal scaffold as a helical peptide mimetic.Chemistry (Weinheim an der Bergstrasse, Germany) · 2010
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Rishi JainDepartment of Chemistry, Yale University, New Haven, CT, USA.
Justin T Ernst
Olaf Kutzki
Hyung Soon Park
Andrew D Hamilton

Funding

VALIDATION OF INHIBITORS OF RHO GTPASES FOR CANCER TREATMENTU19CA067771 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI SCHONBRUNN, ERNST · 1995 to 2009
$8.9M
MOLECULAR RECOGNITION IN BIOMIMETIC RECEPTORSR01GM035208 · NIGMS · YALE UNIVERSITY · PI HAMILTON, ANDREW D · 1986 to 2009
$2.2M
NCI NIH HHS CA67771NIGMS NIH HHS GM35208
6 · The paper itself

Abstract

The design of synthetic agents to disrupt protein-protein interactions has received relatively little attention in recent years. In this review we describe strategies for targeting different types of protein surfaces using mimetics of protein secondary or tertiary structure. In this way strong and selective binding to a protein surface has be achieved and disruption of clinically important protein-protein interactions has been demonstrated in models of human disease.

Indexed as

Amino Acid SequenceBiochemistryChymotrypsinCytochrome-c PeroxidaseCytochromes cMolecular MimicryMolecular Sequence DataOrganic ChemicalsPlatelet-Derived Growth FactorProtein ConformationProteinsReceptors, Platelet-Derived Growth FactorChymotrypsinCytochrome-c PeroxidaseCytochromes cOrganic ChemicalsPlatelet-Derived Growth FactorProteinsReceptors, Platelet-Derived Growth Factor

Identifiers

PMID15209160

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.