ArticlePLoS biology2004
Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control.
Article in PLoS biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed.
- Fluorescent sensors for intracellular signaling in the brain: imaging neurons, glia, and vascular cells.Neurophotonics · 2025Article
- Wide-field imaging in behaving mice as a tool to study cognitive function.Neurophotonics · 2024Review
- Bilateral and symmetric glycinergic and glutamatergic projections from the LSO to the IC in the CBA/CaH mouse.Frontiers in neural circuits · 2024Article
- Calcium imaging: a technique to monitor calcium dynamics in biological systems.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Review
- Imaging of Endoplasmic Reticulum CaFrontiers in endocrinology · 2020Article
- Genetically Encoded Calcium Indicators Can Impair Dendrite Growth of Cortical Neurons.Frontiers in cellular neuroscience · 2020Article
- Stimulation strategies for selective activation of retinal ganglion cell soma and threshold reduction.Journal of neural engineering · 2019Article
- Article
- Thy1 transgenic mice expressing the red fluorescent calcium indicator jRGECO1a for neuronal population imaging in vivo.PloS one · 2018Article
- T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse.eLife · 2017Article
- In vivo imaging of neural activity.Nature methods · 2017Review
- Green fluorescent genetically encoded calcium indicator based on calmodulin/M13-peptide from fungi.PloS one · 2017Article
- An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator.PloS one · 2017Article
- General Anesthetic Conditions Induce Network Synchrony and Disrupt Sensory Processing in the Cortex.Frontiers in cellular neuroscience · 2016Article
- Inducible and combinatorial gene manipulation in mouse brain.Frontiers in cellular neuroscience · 2015Article
- Red fluorescent genetically encoded Ca2+ indicators for use in mitochondria and endoplasmic reticulum.The Biochemical journal · 2014Article
- Lab-on-a-brain: implantable micro-optical fluidic devices for neural cell analysis in vivo.Scientific reports · 2014Article
- Optical neural interfaces.Annual review of biomedical engineering · 2014Review
- Astrocyte Ca²⁺ signalling: an unexpected complexity.Nature reviews. Neuroscience · 2014Review
- Monitoring activity in neural circuits with genetically encoded indicators.Frontiers in molecular neuroscience · 2014Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Genetically encoded fluorescent calcium indicator proteins (FCIPs) are promising tools to study calcium dynamics in many activity-dependent molecular and cellular processes. Great hopes-for the measurement of population activity, in particular-have therefore been placed on calcium indicators derived from the green fluorescent protein and their expression in (selected) neuronal populations. Calcium transients can rise within milliseconds, making them suitable as reporters of fast neuronal activity. We here report the production of stable transgenic mouse lines with two different functional calcium indicators, inverse pericam and camgaroo-2, under the control of the tetracycline-inducible promoter. Using a variety of in vitro and in vivo assays, we find that stimuli known to increase intracellular calcium concentration (somatically triggered action potentials (APs) and synaptic and sensory stimulation) can cause substantial and rapid changes in FCIP fluorescence of inverse pericam and camgaroo-2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.