ArticlePLoS biology2004
Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus.
Article in PLoS biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Gene function predicts divergence across molecular levels.bioRxiv : the preprint server for biology · 2026Article
- Experimental introgression in Drosophila: Asymmetric postzygotic isolation associated with chromosomal inversions and an incompatibility locus on the X chromosome.Molecular ecology · 2023Article
- The importance of intrinsic postzygotic barriers throughout the speciation process.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish.Science (New York, N.Y.) · 2020Article
- Evaluation ofJournal of genetics · 2020Article
- Recurrent Amplification of the Heterochromatin Protein 1 (HP1) Gene Family across Diptera.Molecular biology and evolution · 2018Article
- Cytoplasmic-Nuclear Incompatibility Between Wild Isolates ofG3 (Bethesda, Md.) · 2017Article
- Recurrent Innovation at Genes Required for Telomere Integrity in Drosophila.Molecular biology and evolution · 2017Article
- Article
- Hybridization in Plants: Old Ideas, New Techniques.Plant physiology · 2017Review
- The Drosophila bipectinata species complex: degree of sterility and dystrophied ovaries in interspecific hybrid females.Journal of genetics · 2016Article
- Suppression of F1 Male-Specific Lethality in Caenorhabditis Hybrids by cbr-him-8.G3 (Bethesda, Md.) · 2015Article
- Lineage-Specific Evolution of the Complex Nup160 Hybrid Incompatibility Between Drosophila melanogaster and Its Sister Species.Genetics · 2015Article
- Evidence of natural selection acting on a polymorphic hybrid incompatibility locus in Mimulus.Genetics · 2015Article
- Limited gene misregulation is exacerbated by allele-specific upregulation in lethal hybrids between Drosophila melanogaster and Drosophila simulans.Molecular biology and evolution · 2014Article
- Characterisation of Indica Special Protein (ISP), a marker protein for the differentiation of Oryza sativa subspecies indica and japonica.International journal of molecular sciences · 2014Article
- The Hmr and Lhr hybrid incompatibility genes suppress a broad range of heterochromatic repeats.PLoS genetics · 2014Article
- Article
- Article
- Drosophila americana as a model species for comparative studies on the molecular basis of phenotypic variation.Genome biology and evolution · 2013Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Interspecific hybrid lethality and sterility are a consequence of divergent evolution between species and serve to maintain the discrete identities of species. The evolution of hybrid incompatibilities has been described in widely accepted models by Dobzhansky and Muller where lineage-specific functional divergence is the essential characteristic of hybrid incompatibility genes. Experimentally tractable models are required to identify and test candidate hybrid incompatibility genes. Several Drosophila melanogaster genes involved in hybrid incompatibility have been identified but none has yet been shown to have functionally diverged in accordance with the Dobzhansky-Muller model. By introducing transgenic copies of the X-linked Hybrid male rescue (Hmr) gene into D. melanogaster from its sibling species D. simulans and D. mauritiana, we demonstrate that Hmr has functionally diverged to cause F1 hybrid incompatibility between these species. Consistent with the Dobzhansky-Muller model, we find that Hmr has diverged extensively in the D. melanogaster lineage, but we also find extensive divergence in the sibling-species lineage. Together, these findings implicate over 13% of the amino acids encoded by Hmr as candidates for causing hybrid incompatibility. The exceptional level of divergence at Hmr cannot be explained by neutral processes because we use phylogenetic methods and population genetic analyses to show that the elevated amino-acid divergence in both lineages is due to positive selection in the distant past-at least one million generations ago. Our findings suggest that multiple substitutions driven by natural selection may be a general phenomenon required to generate hybrid incompatibility alleles.
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