ArticleOncogene2004
p53-dependent transcription can exhibit both on/off and graded response after genotoxic stress.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The Relationship between p53-Positive Neurons and Dark Neurons in the Hippocampus of Rats after Surgical Interventions on the Nasal Septum.Doklady. Biochemistry and biophysics · 2022Article
- HSP70 mediates survival in apoptotic cells-Boolean network prediction and experimental validation.Frontiers in cellular neuroscience · 2015Article
- SN50 enhances the effects of LY294002 on cell death induction in gastric cancer cell line SGC7901.Archives of medical science : AMS · 2013Article
- All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin.Toxicology and applied pharmacology · 2013Article
- Surf the post-translational modification network of p53 regulation.International journal of biological sciences · 2012Review
- Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Autocatalytic genetic networks modeled by piecewise-deterministic Markov processes.Journal of mathematical biology · 2010Article
- Noncanonical DNA motifs as transactivation targets by wild type and mutant p53.PLoS genetics · 2008Article
- Switch-like genes populate cell communication pathways and are enriched for extracellular proteins.BMC genomics · 2008Article
- Binary gene induction and protein expression in individual cells.Theoretical biology & medical modelling · 2006Article
- Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores.Biophysical journal · 2006Article
- Current status of transcriptional regulation systems.Cytotechnology · 2006Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The p53 protein is a central player in cellular response to DNA damage. Induction of p53 by DNA-damaging agents involves elevation of its steady-state level and activation of its potency as a transcription factor. In the cell population, these responses can occur either homogeneously (where every single cell responds simultaneously and similarly to its neighbor) or heterogeneously (where only some cells of a population respond and the number of these increases with increasing dose of inducer). We have studied here the p53 response to DNA-damaging agents (camptothecin, mitomycin C) in individual cells. We show that the level of p53 protein is increased in every single cell of the population homogeneously, while the p53-dependent transcription can be subject to an on/off-type response. Depending on the structure of the target promoter, p53-dependent transcription can be regulated according to the binary or graded model. The on/off-type transcriptional activation pattern of p53 defines two distinct subpopulations of cells after DNA damage.
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15208667What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.