ArticleRNA (New York, N.Y.)2004
Long-term evolution of the S788 fungal nuclear small subunit rRNA group I introns.
Article in RNA (New York, N.Y.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Characterization of group I introns in generating circular RNAs as vaccines.Nucleic acids research · 2025Article
- Modeling in yeast how rDNA introns slow growth and increase desiccation tolerance in lichens.G3 (Bethesda, Md.) · 2021Article
- Review
- Polymorphism in Mitochondrial Group I Introns amongFrontiers in microbiology · 2018Article
- Low selection pressure aids the evolution of cooperative ribozyme mutations in cells.The Journal of biological chemistry · 2013Article
- Article
- Toward predicting self-splicing and protein-facilitated splicing of group I introns.RNA (New York, N.Y.) · 2008Article
- RADAR: a web server for RNA data analysis and research.Nucleic acids research · 2007Article
- Phylogenetic analyses suggest reverse splicing spread of group I introns in fungal ribosomal DNA.BMC evolutionary biology · 2005Article
- Divergent histories of rDNA group I introns in the lichen family Physciaceae.Journal of molecular evolution · 2005Article
- Site-specific reverse splicing of a HEG-containing group I intron in ribosomal RNA.Nucleic acids research · 2005Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More than 1000 group I introns have been identified in fungal rDNA. Little is known, however, of the splicing and secondary structure evolution of these ribozymes. Here, we use a combination of comparative and biochemical methods to address the evolution and splicing of a vertically inherited group I intron found at position 788 in the fungal small subunit (S) rRNA. The ancestral state of the S788 intron contains a highly conserved core and an extended P5 domain typical of IC1 introns. In contrast, the more derived introns have lost most of P5, and have an accelerated divergence rate within the core region with three functionally important substitutions that unambiguously separate them from the ancestral pool. Of 14 S788 group I introns that were tested for splicing, five, all of the ancestral type, were able to self-splice and produced intron RNA circles in vitro. The more derived S788 introns did not self-splice, and potentially rely on fungal-specific factors to facilitate splicing. In summary, we demonstrate one possible fate of vertically inherited group I introns, the loss of secondary structure elements, lessened selective constraints in the intron core, and ultimately, dependence on host-mediated splicing.
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