ArticleRNA (New York, N.Y.)2004
Pseudouridine-guide RNAs and other Cbf5p-associated RNAs in Euglena gracilis.
Article in RNA (New York, N.Y.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
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- Article
- Seasonal diversity of planktonic protists in Southwestern Alberta rivers over a 1-year period as revealed by terminal restriction fragment length polymorphism and 18S rRNA gene library analyses.Applied and environmental microbiology · 2012Article
- RNA-seq analysis of small RNPs in Trypanosoma brucei reveals a rich repertoire of non-coding RNAs.Nucleic acids research · 2012Article
- Clustered organization, polycistronic transcription, and evolution of modification-guide snoRNA genes in Euglena gracilis.Molecular genetics and genomics : MGG · 2012Article
- Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase.Genes & development · 2011Article
- Structural and functional evidence of high specificity of Cbf5 for ACA trinucleotide.RNA (New York, N.Y.) · 2011Article
- Strong dependence between functional domains in a dual-function snoRNA infers coupling of rRNA processing and modification events.Nucleic acids research · 2010Article
- U3 snoRNA genes are multi-copy and frequently linked to U5 snRNA genes in Euglena gracilis.BMC genomics · 2009Article
- Psiscan: a computational approach to identify H/ACA-like and AGA-like non-coding RNA in trypanosomatid genomes.BMC bioinformatics · 2008Article
- Different mechanisms for pseudouridine formation in yeast 5S and 5.8S rRNAs.Molecular and cellular biology · 2008Article
- Genome-wide analysis of C/D and H/ACA-like small nucleolar RNAs in Leishmania major indicates conservation among trypanosomatids in the repertoire and in their rRNA targets.Eukaryotic cell · 2007Article
- Identification of determinants in the protein partners aCBF5 and aNOP10 necessary for the tRNA:Psi55-synthase and RNA-guided RNA:Psi-synthase activities.Nucleic acids research · 2007Article
- Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA.RNA (New York, N.Y.) · 2006Article
- Genome-wide analyses of two families of snoRNA genes from Drosophila melanogaster, demonstrating the extensive utilization of introns for coding of snoRNAs.RNA (New York, N.Y.) · 2005Article
- A genome-wide analysis of C/D and H/ACA-like small nucleolar RNAs in Trypanosoma brucei reveals a trypanosome-specific pattern of rRNA modification.RNA (New York, N.Y.) · 2005Article
- Evolutionary patterns of non-coding RNAs.Theory in biosciences = Theorie in den Biowissenschaften · 2005Article
- Number, position, and significance of the pseudouridines in the large subunit ribosomal RNA of Haloarcula marismortui and Deinococcus radiodurans.RNA (New York, N.Y.) · 2005Article
- Unusual features of fibrillarin cDNA and gene structure in Euglena gracilis: evolutionary conservation of core proteins and structural predictions for methylation-guide box C/D snoRNPs throughout the domain Eucarya.Nucleic acids research · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eukaryotes, box H/ACA small nucleolar RNAs (snoRNAs) guide sites of pseudouridine (Psi) formation in rRNA. These snoRNAs reside in RNP complexes containing the putative Psi synthase, Cbf5p. In this study we have identified Cbf5p-associated RNAs in Euglena gracilis, an early diverging eukaryote, by immunoprecipitating Cbf5p-containing complexes from cellular extracts. We characterized one box H/ACA-like RNA which, however, does not appear to guide Psi formation in rRNA. We also identified four single Psi-guide box AGA RNAs. We determined target sites for these putative Psi-guide RNAs and confirmed that the predicted Psi modifications do, in fact, occur at these positions in Euglena rRNA. The Cbf5p-associated snoRNAs appear to be encoded by multicopy genes, some of which are clustered in the genome together with methylation-guide snoRNA genes. These modification-guide snoRNAs and snoRNA genes are the first ones to be reported in euglenid protists, the evolutionary sister group to the kinetoplastid protozoa. Unexpectedly, we also found and have partially characterized a selenocysteine tRNA homolog in the anti-Cbf5p-immunoprecipitated sample.
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