Trial reportContraception2004
Single and multiple exposure tolerance study of polystyrene sulfonate gel: a phase I safety and colposcopy study.
Trial report in Contraception, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Vaginal microbicide and diaphragm use for sexually transmitted infection prevention: a randomized acceptability and feasibility study among high-risk women in Madagascar.Sexually transmitted diseases · 2008Trial
- Effects of long-term use of nonoxynol-9 on vaginal flora.Obstetrics and gynecology · 2006Trial
- Non-Hormonal Contraception.Journal of clinical medicine · 2023Review
- Antiviral activities of four marine sulfated glycans against adenovirus and human cytomegalovirus.Antiviral research · 2021Article
- Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1.Virology journal · 2012Article
- Feasibility of Repurposing the Polyanionic Microbicide, PPCM, for Prophylaxis against HIV Transmission during ART.ISRN obstetrics and gynecology · 2011Article
- Clinical evaluation of microbicide formulations.Antiviral research · 2010Review
- Development of topical microbicides to prevent the sexual transmission of HIV.Antiviral research · 2010Review
- Differential Sensitivity of Lactobacillus spp. to Inhibition by Candidate Topical Microbicides.Probiotics and antimicrobial proteins · 2009Article
- Vaginal drug delivery systems for HIV prevention.The AAPS journal · 2009Review
- Willingness to use microbicides is affected by the importance of product characteristics, use parameters, and protective properties.Journal of acquired immune deficiency syndromes (1999) · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectivesTo evaluate symptoms and signs of genital irritation, vaginal leakage and acceptability of polystyrene sulfonate (PSS), which is being studied as a vaginal contraceptive and microbicide.
methodsForty-nine women applied 2.5 mL of either 5% PSS, 10% PSS, PSS vehicle, or Conceptrol (a marketed spermicidal product containing 4% nonoxynol-9) for 6 consecutive days.
resultsAll women completed the study except one in the Conceptrol group who experienced vaginal symptoms after her first use and was discontinued. After both the first use and after all uses, irritation was seen among more women in the Conceptrol group than in the PSS groups, reaching statistical significance with regard to any evidence of irritation, signs of irritation and product-related irritation. There were no adverse events that were serious, unexpected and related to product use in any group. The 5% concentration of PSS may be preferable in terms of leakage and acceptability.
conclusionThe results suggest that PSS has a safety profile comparable to that of the marketed nonoxynol-9 product, Conceptrol, and appears to be associated with less genital irritation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.