ReviewBiology of the cell2004
Modeling cell signaling networks.
Review in Biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Mesoscale simulations of membrane-tethered reactions to parameterize cell-scale models of signaling.Biophysical journal · 2026Article
- Gene regulatory and biomolecular networks and their multifaceted biotechnological applications.World journal of microbiology & biotechnology · 2026Review
- Calibrating tissue level PDE models of ligand dynamics using single cell and spatial transcriptomics data.NPJ systems biology and applications · 2026Article
- Mesoscale simulations of membrane-tethered reactions to parameterize cell-scale models of signaling.bioRxiv : the preprint server for biology · 2025Article
- An agent-based modelling framework to study growth mechanisms inRoyal Society open science · 2024Article
- kboolnet: a toolkit for the verification, validation, and visualization of reaction-contingency (rxncon) models.BMC bioinformatics · 2023Article
- Mutual repression between JNK/AP-1 and JAK/STAT stratifies senescent and proliferative cell behaviors during tissue regeneration.PLoS biology · 2023Article
- Physiological significance of bistable circuit design in metabolic homeostasis: role of integrated insulin-glucagon signalling network.Molecular biology reports · 2022Review
- PseudoGA: cell pseudotime reconstruction based on genetic algorithm.Nucleic acids research · 2021Article
- Virtual Transcriptomics: Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Stability Analysis of a Signaling Circuit with Dual Species of GTPase Switches.Bulletin of mathematical biology · 2021Article
- Impact of explicit area scaling on kinetic models involving multiple compartments.BMC bioinformatics · 2021Article
- Modeling the Critical Activation of Chaperone Machinery in Protein Folding.Advances in experimental medicine and biology · 2020Article
- Mathematical Modeling of p53 Pathways.International journal of molecular sciences · 2019Review
- Soft Set Theory for Decision Making in Computational Biology under Incomplete Information.IEEE access : practical innovations, open solutions · 2019Article
- Learning time-varying information flow from single-cell epithelial to mesenchymal transition data.PloS one · 2018Article
- Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions: Verification by ODE Modeling and RNA Sequencing.Frontiers in physiology · 2018Article
- Modulation of gap junction-associated Cx43 in neural stem/progenitor cells following traumatic brain injury.Brain research bulletin · 2017Article
- Complexity: the organizing principle at the interface of biological (dis)order.Journal of genetics · 2017Review
- Quantitative Adverse Outcome Pathways and Their Application to Predictive Toxicology.Environmental science & technology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Cell signaling pathways interact with one another to form networks in mammalian systems. Such networks are complex in their organization and exhibit emergent properties such as bistability and ultrasensitivity. Analysis of signaling networks requires a combination of experimental and theoretical approaches including the development and analysis of models. This review focuses on theoretical approaches to understanding cell signaling networks. Using heterotrimeric G protein pathways an example, we demonstrate how interactions between two pathways can result in a network that contains a positive feedback loop and function as a switch. Different mathematical approaches that are currently used to model signaling networks are described, and future challenges including the need for databases as well as enhanced computing environments are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.