ArticleJournal of bacteriology2004
Free and hemophore-bound heme acquisitions through the outer membrane receptor HasR have different requirements for the TonB-ExbB-ExbD complex.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- Article
- The modification of heme special importer to improve the production of active hemoglobins in Escherichia coli.Biotechnology letters · 2024Article
- Transcription regulation of iron carrier transport genes by ECF sigma factors through signaling from the cell surface into the cytoplasm.FEMS microbiology reviews · 2022Article
- A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins.eLife · 2020Article
- Article
- Gallium-Protoporphyrin IX InhibitsFrontiers in cellular and infection microbiology · 2017Article
- Metabolite-driven Regulation of Heme Uptake by the Biliverdin IXβ/δ-Selective Heme Oxygenase (HemO) of Pseudomonas aeruginosa.The Journal of biological chemistry · 2016Article
- Structural basis for haem piracy from host haemopexin by Haemophilus influenzae.Nature communications · 2016Article
- Gene expression changes in Porphyromonas gingivalis W83 after inoculation in rat oral cavity.BMC microbiology · 2015Article
- Spectroscopic Determination of Distinct Heme Ligands in Outer-Membrane Receptors PhuR and HasR of Pseudomonas aeruginosa.Biochemistry · 2015Article
- Differential contributions of the outer membrane receptors PhuR and HasR to heme acquisition in Pseudomonas aeruginosa.The Journal of biological chemistry · 2015Article
- Metal limitation and toxicity at the interface between host and pathogen.FEMS microbiology reviews · 2014Review
- Regulation of iron transport systems in Enterobacteriaceae in response to oxygen and iron availability.Journal of inorganic biochemistry · 2014Review
- Article
- Small molecule antivirulents targeting the iron-regulated heme oxygenase (HemO) of P. aeruginosa.Journal of medicinal chemistry · 2013Article
- Article
- Heme uptake across the outer membrane as revealed by crystal structures of the receptor-hemophore complex.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Bacterial heme-transport proteins and their heme-coordination modes.Archives of biochemistry and biophysics · 2009Review
- NagA-dependent uptake of N-acetyl-glucosamine and N-acetyl-chitin oligosaccharides across the outer membrane of Caulobacter crescentus.Journal of bacteriology · 2008Article
- HasB, the Serratia marcescens TonB paralog, is specific to HasR.Journal of bacteriology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many gram-negative bacteria have specific outer membrane receptors for free heme, hemoproteins, and hemophores. Heme is a major iron source and is taken up intact, whereas hemoproteins and hemophores are not transported: the iron-containing molecule has to be stripped off at the cell surface, with only the heme moiety being taken up. The Serratia marcescens hemophore-specific outer membrane receptor HasR can transport either heme itself or heme bound to the hemophore HasA. This second mechanism is much more efficient and requires a higher TonB-ExbB-ExbD (TonB complex) concentration than does free or hemoglobin-bound heme uptake. This requirement for more of the TonB complex is associated with a higher energy requirement. Indeed, the sensitivity of heme-hemophore uptake to the protonophore carbonyl cyanide m-chlorophenyl hydrazone is higher than that of heme uptake from hemoglobin. We show that a higher TonB complex concentration is required for hemophore dissociation from the receptor. This dissociation is concomitant with heme uptake. We propose that increasing the TonB complex concentration drives more energy to the outer membrane receptor and speeds up the release of empty hemophores, which, if they remained on receptors, would inhibit heme transport.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.