ReviewMediators of inflammation2004
The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion.
Review in Mediators of inflammation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Auditory function and brainstem responses in allergic rhinitis: systematic review and meta-analysis.CoDAS · 2025Pooled it
- Inflammatory markers as determinants of glue-type effusion and recurrent ventilation tube placement.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Co-occurrence of otitis media with effusion and another environment-dependent disease (selected allergic conditions).Postepy dermatologii i alergologii · 2024Article
- Allergy in pathogenesis of Eustachian Tube Dysfunction.The World Allergy Organization journal · 2024Review
- Establishment of novel immortalized middle ear cell lines as models for otitis media.Laryngoscope investigative otolaryngology · 2023Article
- Antiallergic Effects ofPlants (Basel, Switzerland) · 2023Article
- Article
- Intradermal Testing Doubles Identification of Allergy among 110 Immunotherapy-Responsive Patients with Eustachian Tube Dysfunction.Diagnostics (Basel, Switzerland) · 2021Article
- Suppression of lncRNA MALAT1 Reduces LPS- or IL-17A-Induced Inflammatory Response in Human Middle Ear Epithelial Cells via the NF-BioMed research international · 2021Article
- Extranasal Manifestations of Allergy in the Head and Neck.Current allergy and asthma reports · 2020Review
- Otitis media with effusion in adults with patulous Eustachian tube.The Journal of international medical research · 2020Article
- Subversion of host immune responses by otopathogens during otitis media.Journal of leukocyte biology · 2019Review
- Otitis Media with Effusion in Children and the Impact of Risk Factors on Serum Cytokine Levels.Iranian journal of otorhinolaryngology · 2017Article
- Otitis media with effusion and atopy: is there a causal relationship?The World Allergy Organization journal · 2017Review
- Pro-inflammatory interleukins in middle ear effusions from atopic and non-atopic children with chronic otitis media with effusion.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Article
- Influence of Transmural Pressure and Cytoskeletal Structure on NF-κB Activation in Respiratory Epithelial Cells.Cellular and molecular bioengineering · 2010Article
- Otitis media: viruses, bacteria, biofilms and vaccines.The Medical journal of Australia · 2009Article
- Role of nasal allergy in chronic secretory otitis media.Current allergy and asthma reports · 2009Article
- Otitis media as a presenting complaint in childhood immunodeficiency diseases.Current allergy and asthma reports · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation in the middle ear mucosa, which can be provoked by different primary factors such as bacterial and viral infection, local allergic reactions and reflux, is the crucial event in the pathogenesis of otitis media with effusion (OME). Unresolved acute inflammatory responses or defective immunoregulation of middle inflammation can promote chronic inflammatory processes and stimulate the chronic condition of OME. Cytokines are the central molecular regulators of middle ear inflammation and can switch the acute phase of inflammation in the chronic stage and induce molecular-pathological processes leading to the histopathological changes accompanying OME. In this review we present cytokines identified in otitis media, immunoregulatory [interleukin (IL)-2, IL-10, transforming growth factor-beta]) and allergy associated (IL-4, IL-5, granulocyte-macrophage colony-stimulating factor), as crucial molecular regulators, responsible for chronic inflammation in the middle ear and the chronic condition of OME.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.