ArticleNeurochemical research2004
Hypothalamic proline-rich polypeptide protects brain neurons in aluminum neurotoxicosis.
Article in Neurochemical research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Ameliorative Effects of Oyster Protein Hydrolysates on Cadmium-Induced Hepatic Injury in Mice.Marine drugs · 2022Article
- Cancer stem cells as a therapeutic target in 3D tumor models of human chondrosarcoma: An encouraging future for proline rich polypeptide‑1.Molecular medicine reports · 2020Article
- Proline-rich cytokine from neurosecretory granules: a new natural substrate for dipeptidyl peptidase IV.Neurochemical research · 2011Article
- Concepts of neuroendocrine cardiology and neuroendocrine immunology, chemistry and biology of signal molecules.Neurochemical research · 2010Article
- Hypothalamic proline rich polypeptide regulates hematopoiesis.Neurochemical research · 2010Article
- Effect of hypothalamic proline-rich peptide (PRP-1) on neuronal and bone marrow cell apoptosis.Neurochemical research · 2007Article
- Glutamate-related gene expression changes with age in the mouse auditory midbrain.Brain research · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The damaging effect of aluminum ions (Al3+) on the organism is widely investigated in clinics and experiments that indicate its role as a participant in the synthesis of precursors for amyloid proteins and as a potential agent in the ethiology of Alzheimer's disease. It has been shown that Al produces neurotoxic effects. We established that AlCl3 produces degenerative changes in the ultrastructure of Hasserian neurinoma cells in vitro and in L929 fibroblast cells. Proline-rich peptide-1 (PRP-1) isolated from neurosecretory granules of bovine neurohypophysis is a potent antineurodegenerative agent against spinal cord hemisection and crush syndrome-induced neurodegeneration of brain and spinal cord neurons. PRP-1 is one of the neurotrophic brain factors. By electron microscopic study of the rat hippocampus and other tissues, we succeeded in visualizing the epithelioprotectory effect of PRP-1, contributing as a powerful agent in removal of aluminum accumulation in different tissues in experimental aluminum neurotoxicosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.