ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Paradoxical potentiation of neuronal T-type Ca2+ current by ATP at resting membrane potential.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Developmentally Regulated Rebound Depolarization Enhances Spike Timing Precision in Auditory Midbrain Neurons.Frontiers in cellular neuroscience · 2020Article
- A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type CaScientific reports · 2019Article
- The Augmentation of Retinogeniculate Communication during Thalamic Burst Mode.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Sub-synaptic localization of CaBrain structure & function · 2017Article
- Dynamic Analysis of the Conditional Oscillator Underlying Slow Waves in Thalamocortical Neurons.Frontiers in neural circuits · 2016Article
- Neocortical inhibitory activities and long-range afferents contribute to the synchronous onset of silent states of the neocortical slow oscillation.Journal of neurophysiology · 2015Article
- T-type calcium channels cause bursts of spikes in motor but not sensory thalamic neurons during mimicry of natural patterns of synaptic input.Frontiers in cellular neuroscience · 2015Article
- T-type Ca2+ channels in absence epilepsy.Pflugers Archiv : European journal of physiology · 2014Review
- The many faces of T-type calcium channels.Pflugers Archiv : European journal of physiology · 2014Review
- Thalamic post-inhibitory bursting occurs in patients with organic dystonia more often than controls.Brain research · 2013Article
- T-type calcium channels consolidate tonic action potential output of thalamic neurons to neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Midline thalamic paraventricular nucleus neurons display diurnal variation in resting membrane potentials, conductances, and firing patterns in vitro.Journal of neurophysiology · 2012Article
- Bidirectional plasticity in the primate inferior olive induced by chronic ethanol intoxication and sustained abstinence.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Minimal alterations in T-type calcium channel gating markedly modify physiological firing dynamics.The Journal of physiology · 2011Article
- Manipulation of adenosine kinase affects sleep regulation in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Mental arithmetic leads to multiple discrete changes from baseline in the firing patterns of human thalamic neurons.Journal of neurophysiology · 2009Article
- Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels.FEBS letters · 2008Article
- T current potentiation increases the occurrence and temporal fidelity of synaptically evoked burst firing in sensory thalamic neurons.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Modeling thalamocortical cell: impact of ca channel distribution and cell geometry on firing pattern.Frontiers in computational neuroscience · 2008Article
- Ca2+ current of frog vestibular hair cells is modulated by intracellular ATP but not by long-lasting depolarisation.European biophysics journal : EBJ · 2007Article
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Authors and funding
3 authors.
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Abstract
Despite the marked influence on neuronal physiology of the low-voltage activated T-type Ca(2+) currents, little is known about the intracellular pathways and neurotransmitters involved in their regulations. Here, we report that in thalamocortical neurons a phosphorylation mechanism induces an increase both in the current amplitude (1.5 +/- 0.27-fold in the ventrobasal nucleus) and its inactivation kinetics. Dialysis of the neuron with an ATP-free solution suppresses the T-current potentiation, whereas it becomes irreversible in the presence of ATPgammaS. Phosphorylation occurs when the channels are inactivated and is slowly removed when they recover from inactivation and remain in closed states (time constants of the induction and removal of the potentiation: 579 +/- 143 msec and 4.9 +/- 1.1 sec, respectively, at 25 degrees C). The resulting apparent voltage sensitivity of this regulation follows the voltage dependence of the current steady-state inactivation. Thus, the current is paradoxically inhibited when the preceding hyperpolarization is lengthened, and maximal currents are generated after transient hyperpolarizations with a duration (0.7-1.5 sec) that is defined by the balance between the kinetics of the dephosphorylation and deinactivation. In addition, the phosphorylation will facilitate the generation of T current at resting membrane potential. This potentiation, which is specific to sensory thalamocortical neurons, would markedly influence the electroresponsiveness of these neurons and represent the first evidence of a regulation of native Cav3.1 channels.
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