ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Acetylcholine receptors direct rapsyn clusters to the neuromuscular synapse in zebrafish.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- CaOpen biology · 2025Article
- Article
- Allosteric inhibition of muscle-type nicotinic acetylcholine receptors by a neuromuscular blocking agent pancuronium.PloS one · 2023Article
- The Metabolic Stability of the Nicotinic Acetylcholine Receptor at the Neuromuscular Junction.Cells · 2021Review
- Expressing acetylcholine receptors after innervation suppresses spontaneous vesicle release and causes muscle fatigue.Scientific reports · 2017Article
- AChRs Are Essential for the Targeting of Rapsyn to the Postsynaptic Membrane of NMJs in Living Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Defects of the Glycinergic Synapse in Zebrafish.Frontiers in molecular neuroscience · 2016Review
- Rem uncouples excitation-contraction coupling in adult skeletal muscle fibers.The Journal of general physiology · 2015Article
- Zebrafish mutants of the neuromuscular junction: swimming in the gene pool.The journal of physiological sciences : JPS · 2015Review
- The knockdown of αkap alters the postsynaptic apparatus of neuromuscular junctions in living mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A single mutation in the acetylcholine receptor δ-subunit causes distinct effects in two types of neuromuscular synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- eIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation.PLoS biology · 2013Article
- Acetylcholine receptors enable the transport of rapsyn from the Golgi complex to the plasma membrane.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Nicotinic acetylcholine receptor stability at the NMJ deficient in α-syntrophin in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- An acetylcholine receptor lacking both γ and ε subunits mediates transmission in zebrafish slow muscle synapses.The Journal of general physiology · 2011Article
- Paired patch clamp recordings from motor-neuron and target skeletal muscle in zebrafish.Journal of visualized experiments : JoVE · 2010Article
- Regenerated synapses in lamprey spinal cord are sparse and small even after functional recovery from injury.The Journal of comparative neurology · 2010Article
- Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Na(v)1.6a is required for normal activation of motor circuits normally excited by tactile stimulation.Developmental neurobiology · 2010Article
- Postsynaptic development of the neuromuscular junction in mice lacking the gamma-subunit of muscle nicotinic acetylcholine receptor.Journal of molecular neuroscience : MN · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Clustering of nicotinic muscle acetylcholine receptors (AChRs) requires association with intracellular rapsyn, a protein with an intrinsic ability to self-cluster. Previous studies on sofa potato (sop), an AChR null line of zebrafish, have suggested that AChRs may play an active role in subsynaptic localization of rapsyn clusters. To test this proposal directly, we identified and cloned the gene responsible for the sop phenotype and then attempted to rescue subsynaptic localization of the receptor-rapsyn complex in mutant fish. sop contains a leucine to proline mutation at position 28, near the N terminus of the zebrafish AChR delta subunit. Transient expression of mutant delta subunit in sop fish was unable to restore surface expression of muscle AChRs. In contrast, expression of wild-type delta subunit restored the ability of muscle to assemble surface receptors along with the ability of fish to swim. Most importantly, the ability of rapsyn clusters to localize effectively to subsynaptic sites also was rescued in large part. Our results point to direct involvement of the AChR molecule in restricting receptor-rapsyn clusters to the synapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.