ArticleEmerging infectious diseases2004
Influenza A virus PB1-F2 gene in recent Taiwanese isolates.
Article in Emerging infectious diseases, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Virulent PB1-F2 residues: effects on fitness of H1N1 influenza A virus in mice and changes during evolution of human influenza A viruses.Scientific reports · 2018Article
- Role of Autophagy and Apoptosis in the Postinfluenza Bacterial Pneumonia.BioMed research international · 2016Review
- Computational analysis and mapping of novel open reading frames in influenza A viruses.PloS one · 2014Article
- Non-avian animal reservoirs present a source of influenza A PB1-F2 proteins with novel virulence-enhancing markers.PloS one · 2014Article
- A novel cytotoxic sequence contributes to influenza A viral protein PB1-F2 pathogenicity and predisposition to secondary bacterial infection.Journal of virology · 2014Article
- Article
- Surveillance in Eastern India (2007-2009) revealed reassortment event involving NS and PB1-F2 gene segments among co-circulating influenza A subtypes.Virology journal · 2012Article
- Differential localization and function of PB1-F2 derived from different strains of influenza A virus.Journal of virology · 2010Article
- A complicated message: Identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA.Journal of virology · 2009Article
- Codon conservation in the influenza A virus genome defines RNA packaging signals.Nucleic acids research · 2007Article
- Influenza A virus PB1-F2 gene.Emerging infectious diseases · 2006Article
- Genomic signatures of human versus avian influenza A viruses.Emerging infectious diseases · 2006Article
- Laboratory-based surveillance and molecular epidemiology of influenza virus in Taiwan.Journal of clinical microbiology · 2005Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Influenza A virus contains eight RNA segments and encodes 10 viral proteins. However, an 11th protein, called PB1-F2, was found in A/Puerto Rico/8/34 (H1N1). This novel protein is translated from an alternative open reading frame (ORF) in the PB1 gene. We analyzed the PB1 gene of 42 recent influenza A isolates in Taiwan, including 24 H1N1 and 18 H3N2 strains. One H1N1 isolate and 17 H3N2 isolates contained the entire PB1-F2 ORF of 90 residues, three amino acids (aa) longer than the PB1-F2 of A/Puerto Rico/8/34 at the C terminal. The one remaining H3N2 isolate encoded a truncated PB1-F2 with 79 residues. The other 23 H1N1 isolates contained a truncated PB1-F2 of 57 aa. Phylogenetic analysis of both the HA and the PB1 genes showed that they shared similar clustering of these Taiwanese isolates, suggesting that no obvious reassortment occurred between the two genomic segments.
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