ArticleGene expression2004
Mouse Huntington's disease homolog mRNA levels: variation and allele effects.
Article in Gene expression, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Slc1a3-2A-CreERT2 mice reveal unique features of Bergmann glia and augment a growing collection of Cre drivers and effectors in the 129S4 genetic background.Scientific reports · 2021Article
- Refined protocols of tamoxifen injection for inducible DNA recombination in mouse astroglia.Scientific reports · 2018Article
- Allelic series of Huntington's disease knock-in mice reveals expression discorrelates.Human molecular genetics · 2016Article
- Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease.Human molecular genetics · 2015Article
- Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.Nature communications · 2013Article
- Mouse models of polyglutamine diseases: review and data table. Part I.Molecular neurobiology · 2012Review
- Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.Human molecular genetics · 2011Article
- Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats.PloS one · 2011Article
- Early autophagic response in a novel knock-in model of Huntington disease.Human molecular genetics · 2010Article
- Linking SNPs to CAG repeat length in Huntington's disease patients.Nature methods · 2008Article
- Transcription-induced CAG repeat contraction in human cells is mediated in part by transcription-coupled nucleotide excision repair.Molecular and cellular biology · 2007Article
- Article
- Allele-specific conditional destabilization of glutamine repeat mRNAs.Gene expression · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Huntington's disease homolog (Hdh) mRNA levels in mice with different Hdh alleles were measured. Brain Hdh mRNA levels varied up to threefold in genetically identical wild-type mice, indicating nongenetic factors influence Hdh expression. Striatal Hdh mRNA levels from an allele with a repeat expanded to 150 CAGs were diminished compared with wild-type and showed variation that might contribute to phenotypic variability in the Hdh(CAG)150 knock-in mouse model. To determine whether Hdh mRNA levels are tightly regulated, we assessed these levels in mice heterozygous for a deletion of the Hdh promoter. The loss of one allele reduced Hdh mRNA levels in most tissues, suggesting mechanisms to maintain Hdh mRNA levels are not in effect and should not impede therapies designed to destroy mutant huntingtin mRNA. Finally, we found a correlation between tissue mRNA levels and the susceptibility of the Hdh locus to Cre-mediated deletion. The two tissues with the highest levels of Hdh mRNA, testes and brain, were the only tissues susceptible to Cre-mediated recombination between loxP sites at Hdh locus. In contrast, the same Cre-expressing line caused recombination in every tissue for loxP sites at another genomic location. The pattern of Cre susceptibility at Hdh suggests a correlation between chromatin accessibility and high levels of Hdh expression in testes and brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.