ArticleThe Journal of clinical investigation2004
Poliovirus tropism and attenuation are determined after internal ribosome entry.
Article in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 62 citations in OpenAlex.
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- Structural diversity and biological role of the 5' untranslated regions of picornavirus.RNA biology · 2023Review
- Detection of recombinant breakpoint in the genome of human enterovirus E11 strain associated with a fatal nosocomial outbreak.Virology journal · 2022Article
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- Pathogenicity and virulence of hepatitis A virus.Virulence · 2021Review
- Deformed wing virus variant shift from 2010 to 2016 in managed and feral UK honey bee colonies.Archives of virology · 2021Article
- The Nuclear Pore Complex Is a Key Target of Viral Proteases to Promote Viral Replication.Viruses · 2021Review
- Bovine Coronavirus: Variability, Evolution, and Dispersal Patterns of a No Longer Neglected Betacoronavirus.Viruses · 2020Article
- Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence.Cell host & microbe · 2020Article
- Molecular Pathogenicity of Enteroviruses Causing Neurological Disease.Frontiers in microbiology · 2020Review
- Accumulation and Competition Amongst Deformed Wing Virus Genotypes in Naïve Australian Honeybees Provides Insight Into the Increasing Global Prevalence of Genotype B.Frontiers in microbiology · 2020Article
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- Targeting PVR (CD155) and its receptors in anti-tumor therapy.Cellular & molecular immunology · 2019Review
- Molecular mechanism of poliovirus Sabin vaccine strain attenuation.The Journal of biological chemistry · 2018Article
- Enterovirus D68 and acute flaccid myelitis-evaluating the evidence for causality.The Lancet. Infectious diseases · 2018Review
- Identification of the interaction of VP1 with GM130 which may implicate in the pathogenesis of CVB3-induced acute pancreatitis.Scientific reports · 2015Article
- Ebola: translational science considerations.Journal of translational medicine · 2015Review
- Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.Bioinformation · 2015Article
- Analysis of a non-structural gene reveals evidence of possible hepatitis C virus (HCV) compartmentalization.Journal of medical virology · 2012Article
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2 authors at 1 institution in 1 country.
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Abstract
Poliovirus replication is limited to a few organs, including the brain and spinal cord. This restricted tropism may be a consequence of organ-specific differences in translation initiation by the poliovirus internal ribosome entry site (IRES). A C-to-U mutation at base 472 in the IRES of the Sabin type 3 poliovirus vaccine strain, known to attenuate neurovirulence, may further restrict tropism by eliminating viral replication in the CNS. To determine the relationship between IRES-mediated translation and poliovirus tropism, recombinant human adenoviruses were used to express bicistronic mRNAs in murine organs. The IRESs of poliovirus, the cardiotropic coxsackievirus B3 (CVB3), and the hepatotropic hepatitis C virus (HCV) mediate translation in many organs, including those that do not support viral replication. A translation defect associated with the Sabin type 3 IRES was observed in all organs examined. Poliovirus type 1 and recombinant polioviruses dependent on the IRES of CVB3 or HCV replicate in the CNS of mice and cause paralysis. Although the type 3 Sabin strain is an effective vaccine, polioviruses with a U at base 472 of the IRES cause paralysis in newborn mice. Tropism of wild-type and vaccine strains of poliovirus is therefore determined after internal ribosome entry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.