ArticleMolecular and cellular biology2004
Molecular requirements for gene expression mediated by targeted histone acetyltransferases.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms.Epigenetics & chromatin · 2011Article
- Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- GCN5 is a positive regulator of origins of DNA replication in Saccharomyces cerevisiae.PloS one · 2010Article
- Article
- The SAGA subunit Ada2 functions in transcriptional silencing.Molecular and cellular biology · 2009Article
- In vivo expression of MHC class I genes depends on the presence of a downstream barrier element.PloS one · 2009Article
- Subtelomeric ACS-containing proto-silencers act as antisilencers in replication factors mutants in Saccharomyces cerevisiae.Molecular biology of the cell · 2009Article
- MYST opportunities for growth control: yeast genes illuminate human cancer gene functions.Oncogene · 2007Review
- Article
- Histone H3 Ser10 phosphorylation-independent function of Snf1 and Reg1 proteins rescues a gcn5- mutant in HIS3 expression.Molecular and cellular biology · 2005Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histone acetyltransferases (HATs) play fundamental roles in regulating gene expression. HAT complexes with distinct subunit composition and substrate specificity act on chromatin-embedded genes with different promoter architecture and chromosomal locations. Because requirements for HAT complexes vary, a central question in transcriptional regulation is how different HAT complexes function in different chromosomal contexts. Here, we have tested the ability of targeted yeast HATs to regulate gene expression of an epigenetically silenced locus. Of a panel of HAT fusion proteins targeted to a telomeric reporter gene, Sas3p and Gcn5p selectively increased expression of the silenced gene. Reporter gene expression was not solely dependent on acetyltransferase activity of the targeted HAT. Further analysis of Gcn5p-mediated gene expression revealed collateral requirements for HAT complex subunits Spt8p and Spt3p, which interact with TATA-binding protein, and for a gene-specific transcription factor. These data demonstrate plasticity of gene expression mediated by HATs upon encountering novel promoter architecture and chromatin context. The telomeric location of the reporter gene used in these studies also provides insight into the molecular requirements for heterochromatin boundary formation and for overcoming transcriptional silencing.
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Registered trials
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