ArticleMolecular and cellular biology2004
p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Inhibition of p53 and ATRX increases telomeric recombination in primary fibroblasts.FEBS open bio · 2023Article
- Short Telomeres Induce p53 and Autophagy and Modulate Age-Associated Changes in Cardiac Progenitor Cell Fate.Stem cells (Dayton, Ohio) · 2018Article
- Means to the ends: The role of telomeres and telomere processing machinery in metastasis.Biochimica et biophysica acta · 2016Review
- Correlations of telomere length, P53 mutation, and chromosomal translocation in soft tissue sarcomas.International journal of clinical and experimental pathology · 2015Article
- Genome-wide discovery of genetic variants affecting tamoxifen sensitivity and their clinical and functional validation.Annals of oncology : official journal of the European Society for Medical Oncology · 2013Article
- Twisted epithelial-to-mesenchymal transition promotes progression of surviving bladder cancer T24 cells with hTERT-dysfunction.PloS one · 2011Article
- Neighborhood properties are important determinants of temperature sensitive mutations.PloS one · 2011Article
- MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription.Molecular and cellular biology · 2009Article
- Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins.The Journal of cell biology · 2009Article
- Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA.The Journal of cell biology · 2007Article
- Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.Genes & development · 2005Article
- Alternative mechanisms of telomere lengthening: permissive mutations, DNA repair proteins and tumorigenic progression.Mutation researchReview
- PML body meets telomere: the beginning of an ALTernate ending?Nucleus (Austin, Tex.)Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Telomere stabilization is critical for tumorigenesis. A number of tumors and cell lines use a recombination-based mechanism, alternative lengthening of telomeres (ALT), to maintain telomere repeat arrays. Current data suggest that the mutation of p53 facilitates the activation of this pathway. In addition to its functions in response to DNA damage, p53 also acts to suppress recombination, independent of transactivation activity, raising the possibility that p53 might regulate the ALT mechanism via its role as a regulator of recombination. To test the role of p53 in ALT we utilized inducible alleles of human p53. We show that expression of transactivation-incompetent p53 inhibits DNA synthesis in ALT cell lines but does not affect telomerase-positive cell lines. The expression of temperature-sensitive p53 in clonal cell lines results in ALT-specific, transactivation-independent growth inhibition, due in part to the perturbation of S phase. Utilizing chromatin immunoprecipitation assays, we demonstrate that p53 is associated with the telomeric complex in ALT cells. Furthermore, the inhibition of DNA synthesis in ALT cells by p53 requires intact specific DNA binding and suppression of recombination functions. We propose that p53 causes transactivation-independent growth inhibition of ALT cells by perturbing telomeric recombination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.