ArticleMolecular and cellular biology2004
Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 64 citations in OpenAlex.
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- Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs.Nature communications · 2021Article
- Targeted disruption of galectin 3 in mice delays the first wave of spermatogenesis and increases germ cell apoptosis.Cellular and molecular life sciences : CMLS · 2021Article
- Expression profile of microRNAs in the testes of patients with Klinefelter syndrome.Scientific reports · 2020Article
- Disrupted Gene Networks in Subfertile Hybrid House Mice.Molecular biology and evolution · 2020Article
- Infertility Caused by Inefficient Apoptotic Germ Cell Clearance inMolecular and cellular biology · 2020Article
- Article
- Preclinical studies using miR-32-5p to suppress clear cell renal cell carcinoma metastasis via altering the miR-32-5p/TR4/HGF/Met signaling.International journal of cancer · 2018Article
- TRCell death & disease · 2018Article
- Adult functions for the Drosophila DHR78 nuclear receptor.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- MicroRNA in sperm from Duroc, Landrace and Yorkshire boars.Scientific reports · 2016Article
- Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals.Molecular cancer · 2015Article
- The nuclear receptors of Biomphalaria glabrata and Lottia gigantea: implications for developing new model organisms.PloS one · 2015Article
- Minireview: Pathophysiological roles of the TR4 nuclear receptor: lessons learned from mice lacking TR4.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells.PLoS genetics · 2014Article
- Recent advances in the study of testicular nuclear receptor 4.Journal of Zhejiang University. Science. B · 2013Article
- Reduced osteoblast activity in the mice lacking TR4 nuclear receptor leads to osteoporosis.Reproductive biology and endocrinology : RB&E · 2012Article
- Deficiency in TR4 nuclear receptor abrogates Gadd45a expression and increases cytotoxicity induced by ionizing radiation.Cellular & molecular biology letters · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Testicular orphan nuclear receptor 4 (TR4) is specifically and stage-dependently expressed in late-stage pachytene spermatocytes and round spermatids. In the developing mouse testis, the highest expression of TR4 can be detected at postnatal days 16 to 21 when the first wave of spermatogenesis progresses to late meiotic prophase. Using a knockout strategy to delete TR4 in mice, we found that sperm production in TR4(-/-) mice is reduced. The comparison of testes from developing TR4(+/+) and TR4(-/-) mice shows that spermatogenesis in TR4(-/-) mice is delayed. Analysis of the first wave of spermatogenesis shows that the delay can be due to delay and disruption of spermatogenesis at the end of late meiotic prophase and subsequent meiotic divisions. Seminiferous tubule staging shows that stages X to XII, where late meiotic prophase and meiotic divisions take place, are delayed and disrupted in TR4(-/-) mice. Histological examination of testis sections from TR4(-/-) mice shows degenerated primary spermatocytes and some necrotic tubules. Testis-specific gene analyses show that the expression of sperm 1 and cyclin A1, which are genes expressed at the end of meiotic prophase, was delayed and decreased in TR4(-/-) mouse testes. Taken together, results from TR4(+/+) and TR4(-/-) mice indicate that TR4 is essential for normal spermatogenesis in mice.
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