ArticleAmerican journal of human genetics2004
Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study.
Article in American journal of human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005136 (Family Heart Study), which is not on this map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Family Heart Study (FHS)
Who cites it
37 citing papers in PubMed.
- Phenotypic and genetic variation in leptin as determinants of weight regain.International journal of obesity (2005) · 2011Trial
- Leptin promoter G2548A variant, elevated plasma leptin levels, and increased risk of Type 2 diabetes with CAD in Iranian patients: A genetic association study.Journal of diabetes investigation · 2025Article
- The effect ofBiology of sport · 2022Article
- Leptin Signaling in Obesity and Colorectal Cancer.International journal of molecular sciences · 2022Review
- -2548G>A LEP Polymorphism Is Positively Associated with Increased Leptin and Glucose Levels in Obese Saudi Patients Irrespective of Blood Pressure StatusMedicina (Kaunas, Lithuania) · 2022Article
- A Case-Control Study of the Association of Leptin Gene Polymorphisms with Plasma Leptin Levels and Obesity in the Kerala Population.Journal of obesity · 2022Article
- Leptin and the GA genotype of rs2167270 of theBiomedical reports · 2021Article
- Polymorphisms of leptin-melanocortin system genes associated with obesity in an adult population from BarranquillaBiomedica : revista del Instituto Nacional de Salud · 2020Article
- Methylation of the LEP gene promoter in blood at 12 months and BMI at 4 years of age-a population-based cohort study.International journal of obesity (2005) · 2020Article
- Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women.Molecular genetics & genomic medicine · 2020Article
- Genetic variation, intrauterine growth, and adverse pregnancy conditions predict leptin gene DNA methylation in blood at birth and 12 months of age.International journal of obesity (2005) · 2020Article
- Expression of candidate genes associated with obesity in peripheral white blood cells of Mexican children.Archives of medical science : AMS · 2016Article
- Role of leptin G-2548A polymorphism in age- and gender-specific development of obesity.Journal of biosciences · 2015Article
- In Search of Biomarkers for Idiopathic Scoliosis: Leptin and BMP4 Functional Polymorphisms.Journal of biomarkers · 2015Article
- Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer.International journal of endocrinology · 2015Article
- Leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic Malaysian suburban population.Journal of physiological anthropology · 2014Article
- The genetics of human obesity.Annals of the New York Academy of Sciences · 2013Review
- Article
- Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.PloS one · 2013Article
- Leptin, leptin gene and leptin receptor gene polymorphism in heart failure with preserved ejection fraction.Heart and vessels · 2012Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Linkage of body mass index (BMI) to a broad region of chromosome 7q22-35 has been reported in multiple studies. We previously published a multipoint LOD score of 4.9 at D7S1804 for BMI from the National Heart, Lung, and Blood Institute Family Heart Study. Leptin (LEP), the human homolog of the mouse obesity (ob) gene, is positioned near the linkage peak and is the most prominent candidate gene in this region. Interest in LEP as a susceptibility gene for human obesity has led to numerous linkage and association studies, but the results of these studies are still controversial. In the present study, we employed family-based tests of association with both a quantitative measure of BMI adjusted for age and sex and a dichotomously defined obesity trait. We genotyped 29 single-nucleotide polymorphisms (SNPs) spanning 240 kb around the LEP gene in the 82 extended pedigrees with the strongest evidence for linkage. When the programs TRANSMIT and FBAT were used, a number of SNPs showed association in men but not women, for both the quantitative and qualitative trait definitions (P<.05). Five SNPs (H1328084, H1328083, H1328082, H1328081, and H1328080) positioned 2 kb beyond the previously defined promoter region showed strong association in single-marker and multiple-marker haplotype analysis. This five-marker haplotype (frequency 49% in this sample) is overtransmitted to obese offspring (P=.00005). All five of these SNPs are predicted to modify transcription-factor binding sites. This may indicate new functional variants in an extended promoter region of LEP.
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Registered trials
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