ArticleImmunogenetics2004
cDNA cloning and genomic structure of the duck (Anas platyrhynchos) MHC class I gene.
Article in Immunogenetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Partial molecular characterization, expression pattern and polymorphism analysis of MHC I genes in Chinese domestic goose (Anser cygnoides).Genetics and molecular biology · 2024Article
- Polymorphism of duck MHC class molecules.Immunogenetics · 2019Article
- Structural Definition of Duck Major Histocompatibility Complex Class I Molecules That Might Explain Efficient Cytotoxic T Lymphocyte Immunity to Influenza A Virus.Journal of virology · 2017Article
- Characterization of duck (Anas platyrhynchos) MHC class I gene in two duck lines.Journal of genetics · 2017Article
- Expression of Immune-Related Genes of Ducks Infected with Avian Pathogenic Escherichia coli (APEC).Frontiers in microbiology · 2016Article
- Genetic characterization of MHC class II DQB exon 2 variants in gayal (Biotechnology, biotechnological equipment · 2014Article
- Genetic variability of MHC class II DQB exon 2 alleles in yak (Bos grunniens).Molecular biology reports · 2014Article
- Molecular cloning and functional analysis of the duck TLR4 gene.International journal of molecular sciences · 2013Article
- Characterization of the MHC class II α-chain gene in ducks.Immunogenetics · 2011Article
- MHC class I loci of the Bar-Headed goose (Anser indicus).Genetics and molecular biology · 2010Article
- Complex assembly, crystallization and preliminary X-ray crystallographic studies of duck MHC class I molecule.Acta crystallographica. Section F, Structural biology and crystallization communications · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to provide data for studies on disease resistance, duck MHC class I cDNA (Anpl-MHC I) was cloned from a duck cDNA library and the genome structure was investigated. Anpl-MHC I genes encoded 344-355 amino acids. The genomic organization is composed of eight exons and seven introns. Based on the genetic distance, Anpl-MHC I cDNA from six individuals can be classified into four lineages (from Anpl-UAA to Anpl-UDA). A total of 28 amino acid positions in the peptide-binding domain (PBD) showed high scores by Wu-kabat index analysis. The Anpl-MHC amino acid sequence displayed seven critical HLA-A2amino acids that bind with antigen polypeptides, and have an 83.6-88.5% amino acid homology with each lineage, a 55.2-64.6% amino-acid homology with chicken MHC class I (B-FIV21, B-FIV2, Rfp-Y), and a 40.3-42.8% homology with mammalian MHC class I. Nested PCR detected that Anpl-MHC I can be expressed in the brain, heart, kidney, intestines and bursa. Compared with the human HLA-A2 tertiary structure of the PBD, Anpl-MHC I had an insertion or deletion variation in four domains (A-D). The phlyogenetic tree appears to branch in an order consistent with accepted evolutionary pathways.
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