Trial reportMolecular psychiatry2004
Replication of 1q42 linkage in Finnish schizophrenia pedigrees.
Trial report in Molecular psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 185 citations in OpenAlex.
- Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia.Molecular psychiatry · 2012Pooled it
- A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia.Molecular psychiatry · 2005Trial
- Sex-specific association of IDO1 gene with schizophrenia and imbalanced levels of cytokines and neuroactive kynurenine metabolites in relapsed patients.European archives of psychiatry and clinical neuroscience · 2026Article
- Evidence for an Association Between a pH-Dependent Potassium Channel, TWIK-1, and the Accuracy of Smooth Pursuit Eye Movements.Investigative ophthalmology & visual science · 2024Article
- Mutations in DISC1 alter IPNeuronal signaling · 2021Review
- Disrupted-in-schizophrenia 1 functional polymorphisms and DGenes, brain, and behavior · 2019Article
- The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.Human molecular genetics · 2018Article
- Importance of kynurenine 3-monooxygenase for spontaneous firing and pharmacological responses of midbrain dopamine neurons: Relevance for schizophrenia.Neuropharmacology · 2018Article
- Malformation of the Posterior Cerebellar Vermis Is a Common Neuroanatomical Phenotype of Genetically Engineered Mice on the C57BL/6 Background.Cerebellum (London, England) · 2018Article
- TheOpen biology · 2017Article
- A Gene-Based Analysis of Acoustic Startle Latency.Frontiers in psychiatry · 2017Article
- Stimulation of Synaptic Vesicle Exocytosis by the Mental Disease Gene DISC1 is Mediated by N-Type Voltage-Gated Calcium Channels.Frontiers in synaptic neuroscience · 2016Article
- Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness.Molecular neuropsychiatry · 2015Article
- The cortical thickness phenotype of individuals with DISC1 translocation resembles schizophrenia.The Journal of clinical investigation · 2015Article
- Associating schizophrenia, long non-coding RNAs and neurostructural dynamics.Frontiers in molecular neuroscience · 2015Review
- Neuronal migration abnormalities and its possible implications for schizophrenia.Frontiers in neuroscience · 2015Review
- Common variants in psychiatric risk genes predict brain structure at birth.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1.The European journal of neuroscience · 2014Article
- A Disrupted-in-Schizophrenia 1 Gene Variant is Associated with Clinical Symptomatology in Patients with First-Episode Psychosis.Psychiatry investigation · 2014Article
- DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan.Molecular psychiatry · 2014Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosome 1q has been implicated in the etiology of schizophrenia in several independent studies. However, the peak linkage findings have been dispersed over a large chromosomal region, with negative findings in this region also being reported. Our group has previously observed linkage on chromosome 1q42, maximizing within the DISC1 gene, which has also been implied in the etiology of schizophrenia based on functional studies. In the study presented here, we genotyped 300 polymorphic markers on chromosome 1 using a study sample of 70 families with multiple individuals affected with schizophrenia or related conditions, independent of the study samples in our previous reports. We again found evidence for linkage on 1q42 maximizing within the DISC1 gene (rs1000731, lod=2.70). Further, a haplotype containing the most strongly linked markers showed some evidence of association with the disease. This replicates the previous linkage finding in the same region and constitutes supportive evidence for a susceptibility gene in this region.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.