ArticleProceedings of the National Academy of Sciences of the United States of America2004
Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 81 citations in OpenAlex.
- Impact of resistance exercise on ribosome biogenesis is acutely regulated by post-exercise recovery strategies.Physiological reports · 2016Trial
- Therapeutic advances of targeting receptor tyrosine kinases in cancer.Signal transduction and targeted therapy · 2024Review
- Modeling the consequences of age-linked rDNA hypermethylation with dCas9-directed DNA methylation in human cells.PloS one · 2024Article
- PI3Kα Translocation Mediates Nuclear PtdIns(3,4,5)PMolecular & cellular proteomics : MCP · 2023Article
- Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium.International journal of molecular sciences · 2023Review
- Cell cycle control by the insulin-like growth factor signal: at the crossroad between cell growth and mitotic regulation.Cell cycle (Georgetown, Tex.) · 2023Review
- BMP7 increases protein synthesis in SW1353 cells and determines rRNA levels in a NKX3-2-dependent manner.PloS one · 2022Article
- Insulin-like growth factor 1-receptor signaling stimulates GRP78 expression through the PI3K/AKT/mTOR/ATF4 axis.Cellular signalling · 2020Article
- Review
- Review
- Targeting Insulin Receptor with a Novel Internalizing Aptamer.Molecular therapy. Nucleic acids · 2016Article
- The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability.Nature communications · 2016Article
- Nuclear PI3K signaling in cell growth and tumorigenesis.Frontiers in cell and developmental biology · 2015Review
- Insulin/Insulin-like growth factors in cancer: new roles for the aryl hydrocarbon receptor, tumor resistance mechanisms, and new blocking strategies.Frontiers in endocrinology · 2015Review
- GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling.Journal of cellular physiology · 2012Article
- Nuclear IRS-1 and cancer.Journal of cellular physiology · 2012Review
- Signaling mechanisms in the regulation of renal matrix metabolism in diabetes.Experimental diabetes research · 2012Review
- The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer.PloS one · 2012Article
- Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms.Experimental diabetes research · 2012Review
- Depletion of insulin receptor substrate 2 reverses oncogenic transformation induced by v-src.Acta pharmacologica Sinica · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The insulin-like growth factor I/insulin receptor substrate 1 axis controls, in a nonredundant way, approximately 50% of cell and body size in animals from Drosophila to mice and in cells in culture. Although other factors may also intervene, cell size is strongly dependent on ribosome biogenesis, which is under the control of RNA polymerase I activity. We have previously shown that insulin receptor substrate 1 (IRS-1) translocates to the nuclei and nucleoli, where it binds to the upstream binding factor (UBF) 1, a regulator of RNA polymerase I activity. Activation of UBF1 requires its phosphorylation. However, IRS-1 is not a kinase, and we searched for an intermediate kinase that can phosphorylate UBF1. We demonstrate here that IRS-1 binds also to the phosphatidylinositol 3-kinase (PI3-K) subunits in nuclear extracts, and that the p110 subunit of PI3-K directly phosphorylates and activates UBF1, an exclusively nucleolar protein. The interaction of IRS-1, PI3-K, and UBF1 in the nucleoli provides one of the mechanisms for the effects of IRS-1 on cell and body size.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.