ArticleProceedings of the National Academy of Sciences of the United States of America2004
A detailed physical map of the horse Y chromosome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 70 citations in OpenAlex.
- Standardization of a Sex-Sorting Protocol for Stallion Spermatozoa by Means of Absolute RT-qPCR.International journal of molecular sciences · 2023Article
- Unlocking Horse Y Chromosome Diversity.Genes · 2022Review
- State of the art on the physical mapping of the Y-chromosome in the Bovidae and comparison with other species - A review.Animal bioscience · 2022Article
- "Adopt-a-Tissue" Initiative Advances Efforts to Identify Tissue-Specific Histone Marks in the Mare.Frontiers in genetics · 2021Article
- Molecular screening of XYJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020Article
- The Red Fox Y-Chromosome in Comparative Context.Genes · 2019Article
- Horse Y chromosome assembly displays unique evolutionary features and putative stallion fertility genes.Nature communications · 2018Article
- Y-Single Nucleotide Polymorphisms Diversity in Chinese Indigenous Horse.Asian-Australasian journal of animal sciences · 2015Article
- Analysis of horse genomes provides insight into the diversification and adaptive evolution of karyotype.Scientific reports · 2014Article
- Splice variants and promoter methylation status of the Bovine Vasa Homology (Bvh) gene may be involved in bull spermatogenesis.BMC genetics · 2013Article
- Identification of genetic variation on the horse y chromosome and the tracing of male founder lineages in modern breeds.PloS one · 2013Article
- Random X inactivation in the mule and horse placenta.Genome research · 2012Article
- Evolutionary history of novel genes on the tammar wallaby Y chromosome: Implications for sex chromosome evolution.Genome research · 2012Article
- A gene catalogue of the euchromatic male-specific region of the horse Y chromosome: comparison with human and other mammals.PloS one · 2011Article
- Equine clinical genomics: A clinician's primer.Equine veterinary journal · 2010Review
- An integrated genetic and physical map of homoeologous chromosomes 12 and 26 in Upland cotton (G. hirsutum L.).BMC genomics · 2008Article
- The horse genome derby: racing from map to whole genome sequence.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Review
- Structural variation on the short arm of the human Y chromosome: recurrent multigene deletions encompassing Amelogenin Y.Human molecular genetics · 2007Article
- Mammalian male mutation bias: impacts of generation time and regional variation in substitution rates.Journal of molecular evolution · 2006Article
- MK17, a specific marker closely linked to the gynoecium suppression region on the Y chromosome in Silene latifolia.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2006Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We herein report a detailed physical map of the horse Y chromosome. The euchromatic region of the chromosome comprises approximately 15 megabases (Mb) of the total 45- to 50-Mb size and lies in the distal one-third of the long arm, where the pseudoautosomal region (PAR) is located terminally. The rest of the chromosome is predominantly heterochromatic. Because of the unusual organization of the chromosome (common to all mammalian Y chromosomes), a number of approaches were used to crossvalidate the results. Analysis of the 5,000-rad horse x hamster radiation hybrid panel produced a map spanning 88 centirays with 8 genes and 15 sequence-tagged site (STS) markers. The map was verified by several fluorescence in situ hybridization approaches. Isolation of bacterial artificial chromosome (BAC) clones for the radiation hybrid-mapped markers, end sequencing of the BACs, STS development, and bidirectional chromosome walking yielded 109 markers (100 STS and 9 genes) contained in 73 BACs. STS content mapping grouped the BACs into seven physically ordered contigs (of which one is predominantly ampliconic) that were verified by metaphase-, interphase-, and fiber-fluorescence in situ hybridization and also BAC fingerprinting. The map spans almost the entire euchromatic region of the chromosome, of which 20-25% (approximately 4 Mb) is covered by isolated BACs. The map is presently the most informative among Y chromosome maps in domesticated species, third only to the human and mouse maps. The foundation laid through the map will be critical in obtaining complete sequence of the euchromatic region of the horse Y chromosome, with an aim to identify Y specific factors governing male infertility and phenotypic sex variation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.