ArticleProceedings of the National Academy of Sciences of the United States of America2004
TorI, a response regulator inhibitor of phage origin in Escherichia coli.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
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- Sensory Systems and Transcriptional Regulation inFrontiers in bioengineering and biotechnology · 2022Review
- Experimental Evolution of Escherichia coli K-12 at High pH and with RpoS Induction.Applied and environmental microbiology · 2018Article
- Envelope Stress Responses: An Interconnected Safety Net.Trends in biochemical sciences · 2017Review
- Small proteins can no longer be ignored.Annual review of biochemistry · 2014Review
- Phage-host interactions during pseudolysogeny: Lessons from the Pid/dgo interaction.Bacteriophage · 2013Article
- Article
- DnaJ (Hsp40 protein) binding to folded substrate impacts KplE1 prophage excision efficiency.The Journal of biological chemistry · 2012Article
- Structural basis of response regulator inhibition by a bacterial anti-activator protein.PLoS biology · 2011Article
- Chaperone-assisted excisive recombination, a solitary role for DnaJ (Hsp40) chaperone in lysogeny escape.The Journal of biological chemistry · 2011Article
- MecA dampens transitions to spore, biofilm exopolysaccharide and competence expression by two different mechanisms.Molecular microbiology · 2011Article
- Characterization of the relationship between integrase, excisionase and antirepressor activities associated with a superinfecting Shiga toxin encoding bacteriophage.Nucleic acids research · 2011Article
- Tight regulation of the intS gene of the KplE1 prophage: a new paradigm for integrase gene regulation.PLoS genetics · 2010Article
- A cell-type-specific protein-protein interaction modulates transcriptional activity of a master regulator in Caulobacter crescentus.Molecular cell · 2010Article
- Signal integration in bacterial two-component regulatory systems.Genes & development · 2008Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The torI gene has been identified by using a genetic multicopy approach as a negative regulator of the torCAD operon that encodes the trimethylamine N-oxide reductase respiratory system in Escherichia coli. The negative effect was due to a previously unidentified small ORF (66 aa) of phage origin that we called torI for Tor inhibition. Overexpression of torI led to an 8-fold decrease of the torCAD operon transcription. This operon is positively regulated, in the presence of trimethylamine N-oxide, by a four-step phosphorelay involving the TorS sensor and the TorR response regulator. Epistatic experiments showed that TorI acts downstream of TorS and needs the presence of TorR. In vitro experiments showed that it is neither a TorR phosphatase nor a histidine kinase inhibitor and that it binds to the effector domain of TorR. Unexpectedly, TorI did not impede TorR DNA binding, and we propose that it may prevent RNA polymerase recruitment to the torC promoter. This study thus reveals a previously uncharacterized class of response regulator inhibitors.
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