ArticleThe Journal of experimental medicine2004
Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy.
Article in The Journal of experimental medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
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Who cites it
121 citing papers in PubMed, 506 citations in OpenAlex.
- HLA-DRAllergy · 2025Trial
- Stool microbiome, pH and short/branched chain fatty acids in infants receiving extensively hydrolyzed formula, amino acid formula, or human milk through two months of age.BMC microbiology · 2020Trial
- Oral immunotherapy combined with omalizumab for high-risk cow's milk allergy: a randomized controlled trial.Scientific reports · 2017Trial
- Tolerance induction after specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A in children.Clinical and experimental immunology · 2010Trial
- Clinical efficacy and immune regulation with peanut oral immunotherapy.The Journal of allergy and clinical immunology · 2009Trial
- Increased Tolerance to Less Extensively Heat-Denatured (Baked) Milk Products in Milk-Allergic Children.The journal of allergy and clinical immunology. In practiceTrial
- Mixed Signals: T Cells as Architects of IgE Immunity.Immunological reviews · 2026Review
- Immune Profile After Oral Immunotherapy in Children With Persistent Cow's Milk Protein Allergy.Allergy, asthma & immunology research · 2026Article
- Article
- Gut mucosal immune responses - Implications for celiac disease and food allergy.Seminars in immunology · 2025Review
- Non-immunoglobulin E-mediated gastrointestinal food allergies in children with Down syndrome: An epidemiological study.The World Allergy Organization journal · 2025Article
- The Immunological Mechanisms Involved in the Pathophysiology of Allergic Proctocolitis.Children (Basel, Switzerland) · 2025Article
- Role of human antigen-specific T cells in tolerance and IgE-mediated allergic reactions to food.Frontiers in immunology · 2025Review
- Article
- The renaissance of oral tolerance: merging tradition and new insights.Nature reviews. Immunology · 2025Review
- Article
- Sibling-controlled study of the impact of dietary therapy on the gut microbiota in children with phenylketonuria.Frontiers in nutrition · 2025Article
- Review
- Contribution of T cell subsets to different food allergic diseases.Immunological reviews · 2024Review
- Shrimp allergen extract immunotherapy induces prolonged immune tolerance in a gastro-food allergy mouse model.PloS one · 2024Article
61 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cow's milk allergy in children is often of short duration, which makes this disorder an interesting clinical model for studies of tolerance to dietary antigens. Here, we studied T cell responses in 21 initially allergic children who, after a milk-free period of >2 mo, had cow's milk reintroduced to their diet. Children who outgrew their allergy (tolerant children) had higher frequencies of circulating CD4(+)CD25(+) T cells and decreased in vitro proliferative responses to bovine beta-lactoglobulin in peripheral blood mononuclear cells (PBMCs) compared with children who maintained clinically active allergy. No significant difference in proliferative activity stimulated by the polyclonal mitogen phytohemagglutinin was observed between the two groups. Depletion of CD25(+) cells from PBMCs of tolerant children led to a fivefold increase in in vitro proliferation against beta-lactoglobulin. This suggests that tolerance is associated with the appearance of circulating CD4(+)CD25(+) regulatory T (Treg) cells that are capable of suppressing the effector T cells generated 1 wk after reintroduction of cow's milk. The suppressive function of the CD4(+)CD25(+) Treg cells was shown to be partly cell contact dependent. Collectively, our study provides human data to suggest that mucosal induction of tolerance against dietary antigens is associated with the development of CD4(+)CD25(+) Treg cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.