ArticleThe Journal of cell biology2004
Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 47 citations in OpenAlex.
- BLM Sumoylation Is Required for Replication Stability and Normal Fork Velocity During DNA Replication.Frontiers in molecular biosciences · 2022Article
- The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.Nature communications · 2021Article
- RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR.Cell cycle (Georgetown, Tex.) · 2019Article
- PCNA-Ub polyubiquitination inhibits cell proliferation and induces cell-cycle checkpoints.Cell cycle (Georgetown, Tex.) · 2016Article
- Top3α is required during the convergent migration step of double Holliday junction dissolution.PloS one · 2014Article
- ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair.PloS one · 2014Article
- Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells.Molecular biology of the cell · 2014Article
- DNA damage response: three levels of DNA repair regulation.Cold Spring Harbor perspectives in biology · 2013Review
- FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery.Nucleic acids research · 2013Article
- The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks.Molecular biology of the cell · 2013Article
- BLM SUMOylation regulates ssDNA accumulation at stalled replication forks.Frontiers in genetics · 2013Article
- Hpz1 modulates the G1-S transition in fission yeast.PloS one · 2012Article
- Article
- Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks.Molecular biology of the cell · 2010Article
- SUMO modification regulates BLM and RAD51 interaction at damaged replication forks.PLoS biology · 2009Article
- ATR: an essential regulator of genome integrity.Nature reviews. Molecular cell biology · 2008Review
- RecQ helicases: guardian angels of the DNA replication fork.Chromosoma · 2008Review
- Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.Journal of molecular biology · 2008Article
- DNA structure-induced recruitment and activation of the Fanconi anemia pathway protein FANCD2.Molecular and cellular biology · 2007Article
- Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability.The Biochemical journal · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bloom's syndrome (BS), a disorder associated with genomic instability and cancer predisposition, results from defects in the Bloom's helicase (BLM) protein. In BS cells, chromosomal abnormalities such as sister chromatid exchanges occur at highly elevated rates. Using Xenopus egg extracts, we have studied Xenopus BLM (Xblm) during both unperturbed and disrupted DNA replication cycles. Xblm binds to replicating chromatin and becomes highly phosphorylated in the presence of DNA replication blocks. This phosphorylation depends on Xenopus ATR (Xatr) and Xenopus Rad17 (Xrad17), but not Claspin. Xblm and Xenopus topoisomerase IIIalpha (Xtop3alpha) interact in a regulated manner and associate with replicating chromatin interdependently. Immunodepletion of Xblm from egg extracts results in accumulation of chromosomal DNA breaks during both normal and perturbed DNA replication cycles. Disruption of the interaction between Xblm and Xtop3alpha has similar effects. The occurrence of DNA damage in the absence of Xblm, even without any exogenous insult to the DNA, may help to explain the genesis of chromosomal defects in BS cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.