ArticleBritish journal of pharmacology2004
Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages.
Article in British journal of pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Effect of acute ischemic stroke in 3xTg-AD mouse model of Alzheimer's disease.Scientific reports · 2026Article
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- Microglia in Alzheimer's disease: pathogenesis, mechanisms, and therapeutic potentials.Frontiers in aging neuroscience · 2023Review
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- Matrix metalloproteinase-12 as an endogenous resolution promoting factor following myocardial infarction.Pharmacological research · 2018Review
- Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo.Scientific reports · 2017Article
- Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen-Glucose Deprivation/Reperfusion.International journal of molecular sciences · 2016Article
- The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide.Journal of neuroinflammation · 2016Article
- Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights.Molecular and cellular endocrinology · 2011Review
- Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1.Biochemical pharmacology · 2009Article
- Dexamethasone modulates Salmonella enterica serovar Typhimurium infection in vivo independently of the glucocorticoid-inducible protein annexin-A1.FEMS immunology and medical microbiology · 2008Article
- Annexin-A1: a pivotal regulator of the innate and adaptive immune systems.British journal of pharmacology · 2008Review
- Lack of annexin 1 results in an increase in corticotroph number in male but not female mice.Journal of neuroendocrinology · 2006Article
- Impaired phagocytic mechanism in annexin 1 null macrophages.British journal of pharmacology · 2006Article
- Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation.The American journal of pathology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The role of the glucocorticoid-regulated protein annexin 1 during the process of phagocytosis has been studied using annexin 1 null peritoneal macrophages. Wild type and annexin 1 null macrophages were incubated with several distinct phagocytic targets. No differences were observed in rate or the maximal response with respect to IgG complexes or opsonised zymosan phagocytosis, as assessed by monitoring the production of reactive oxygen species. When annexin 1 null macrophages were incubated with non-opsonised zymosan particles, they exhibited impaired generation of reactive oxygen species, which was linked to a defect in binding of cells to the particles, as determined with fluorescent zymosan. This phenomenon was further confirmed by electron microscopy analysis, where annexin 1 null macrophages internalised fewer non-opsonised zymosan particles. Specific alterations in macrophage plasma membrane markers were observed in the annexin 1 null cells. Whereas no differences in dectin-1 and FcgammaR II/III expression were measured between the two genotypes, decreased membrane CD11b and F4/80 levels were measured selectively in macrophages lacking annexin 1. These cells also responded with an enhanced release of PGE(2) and COX-2 protein expression following addition of the soluble stimulants, LPS and heat-activated IgG. In conclusion, these results suggest that participation of endogenous annexin 1 during zymosan phagocytosis is critical and that this protein plays a tonic inhibitory role during macrophage activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.