ArticleClinical and experimental immunology2004
Polyreactive antigen-binding B (PAB-) cells are widely distributed and the PAB population consists of both B-1+ and B-1- phenotypes.
Article in Clinical and experimental immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Autoantibodies in COVID-19: implications for disease severity and clinical outcomes.Frontiers in immunology · 2024Review
- Autoantibodies targeting neuronal proteins as biomarkers for neurodegenerative diseases.Theranostics · 2022Review
- Homeostasis and regulation of autoreactive B cells.Cellular & molecular immunology · 2020Review
- Evidence to Support a Contribution of Polyreactive Antibodies to HLA Serum Reactivity.Transplantation · 2016Article
- Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation.Scientific reports · 2015Article
- Cryptic B cell response to renal transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013Article
- Polyreactive antibodies plus complement enhance the phagocytosis of cells made apoptotic by UV-light or HIV.Scientific reports · 2013Article
- Polyreactive antibodies in adaptive immune responses to viruses.Cellular and molecular life sciences : CMLS · 2012Review
- Autoantibodies: Focus on anti-DNA antibodies.Self/nonself · 2011Article
- Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells.Journal of autoimmunity · 2007Review
- The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies.Cell host & microbe · 2007Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
B cells that make polyreactive antibodies (PAB+ cells) express polyreactive Ig receptors on their surface and can bind a variety of different antigens. The present study shows that PAB+ cells are widely distributed, are present in varying numbers in different lymphoid organs and that their phenotype varies depending on the organs from which they are isolated. Up to 10 times more cells in PAB+ enriched populations bind antigens as compared to PAB- populations. Comparison of PAB+ with B-1+ cells showed that a high percentage of PAB+ cells are B-1+, but that many PAB+ cells do not express B-1 cell surface markers and, in fact, are B-1-. It is concluded that the B cell population consists of PAB+/B-1+, PAB+/B-1-, PAB-/B-1+, and PAB-/B-1- cells. The presence of PAB+ cells in the thymus points to the possibility that PAB+ cells may carry endogenous host antigens from peripheral tissues to the thymus where they may contribute to immunological tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.