ArticleClinical and experimental immunology2004
Acute infection with influenza virus enhances susceptibility to fatal pneumonia following Streptococcus pneumoniae infection in mice with chronic pulmonary colonization with Pseudomonas aeruginosa.
Article in Clinical and experimental immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Risk Factors for Influenza-Induced Exacerbations and Mortality in Non-Cystic Fibrosis Bronchiectasis.Viruses · 2023Article
- Role of neutrophils in acute viral infection.Immunity, inflammation and disease · 2021Review
- Bacteriophages Could Be a Potential Game Changer in the Trajectory of Coronavirus Disease (COVID-19).PHAGE (New Rochelle, N.Y.) · 2020Review
- Association of influenza with severe pneumonia/empyema in the community, hospital, and healthcare-associated setting.Respiratory medicine case reports · 2016Article
- Role of Autophagy and Apoptosis in the Postinfluenza Bacterial Pneumonia.BioMed research international · 2016Review
- Galectins regulate the inflammatory response in airway epithelial cells exposed to microbial neuraminidase by modulating the expression of SOCS1 and RIG1.Molecular immunology · 2015Article
- Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR.The Journal of biological chemistry · 2015Article
- Article
- Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity.PloS one · 2011Article
- Experimental meningococcal sepsis in congenic transgenic mice expressing human transferrin.PloS one · 2011Article
- Postinfluenza bacterial pneumonia: host defenses gone awry.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2010Review
- Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection.Cell host & microbe · 2010Article
- Critical role of IL-1 receptor-associated kinase-M in regulating chemokine-dependent deleterious inflammation in murine influenza pneumonia.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Influenza A virus neuraminidase enhances meningococcal adhesion to epithelial cells through interaction with sialic acid-containing meningococcal capsules.Infection and immunity · 2009Article
- Two-dimensional gel electrophoresis analysis in simultaneous influenza pneumonia and bacterial infection in mice.Clinical and experimental immunology · 2008Article
- Impact of antifungal treatment on Candida-Pseudomonas interaction: a preliminary retrospective case-control study.Intensive care medicine · 2007Article
- Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infection.Infection and immunity · 2006Article
- Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection.Antimicrobial agents and chemotherapy · 2006Article
- Viral respiratory infections in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2005Review
- Ménage à trois of bacterial and viral pulmonary pathogens delivers coup de grace to the lung.Clinical and experimental immunology · 2004Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We established a mouse model in which fatal pneumonia was induced by pneumococcal superinfection following influenza virus infection in chronic Pseudomonas aeruginosa infected mice. In this mouse model, influenza virus infection caused a significant increase in inflammatory cells, cytokines and severe tissue damage in the lungs of these P. aeruginosa infected mice, before pneumococcal infection. Intrapulmonary virus titres were significantly increased in mice with chronic P. aeruginosa infection, compared with control mice. Neutrophil function analysis showed significant reduction of myeloperoxidase (MPO) activity and lysozyme secretion by influenza virus infection in these mice. Our results suggest that influenza virus infection may play an important role in inducing pneumococcal pneumonia in chronic P. aeruginosa infected mice. Our results suggested that our mouse model is useful for investigating the pathogenesis of influenza virus infection in patients with chronic lung infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.