ArticleImmunology2004
Prenatal exposure to bisphenol A up-regulates immune responses, including T helper 1 and T helper 2 responses, in mice.
Article in Immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Dental sealants and composite restorations and longitudinal changes in immune function markers in children.International journal of paediatric dentistry · 2014Trial
- Deciphering the molecular mechanism of NLRP3 in BPA-mediated toxicity: Implications for targeted therapies.Heliyon · 2024Review
- Integrative transcriptomic profiling uncovers immune and functional responses to bisphenol a across multiple tissues in male mice.Animal cells and systems · 2024Article
- Environmental estrogen exposures alter molecular signaling in immune cells that promote the development of childhood asthma.Molecular immunology · 2023Article
- Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions.Pharmaceutics · 2023Review
- Impact of Environmentally Relevant Concentrations of Bisphenol A (BPA) on the Gene Expression Profile in an In Vitro Model of the Normal Human Ovary.International journal of molecular sciences · 2022Article
- Review
- The effects of bisphenol A given in ovo on bursa of Fabricius development and percentage of acid phosphatase positive lymphocyte in chicken.Environmental science and pollution research international · 2021Article
- Modulation of folliculogenesis in adult laying chickens by bisphenol A and bisphenol S: Perspectives on ovarian morphology and gene expression.Reproductive toxicology (Elmsford, N.Y.) · 2021Article
- Endocrine Disruptor Compounds-A Cause of Impaired Immune Tolerance Driving Inflammatory Disorders of Pregnancy?Frontiers in endocrinology · 2021Review
- Interplay Between Endocrine Disruptors and Immunity: Implications for Diseases of Autoreactive Etiology.Frontiers in pharmacology · 2021Review
- Effect of bisphenol A on human neutrophils immunophenotype.Scientific reports · 2020Article
- Immune Cells in the Uterine Remodeling: Are They the Target of Endocrine Disrupting Chemicals?Frontiers in immunology · 2020Review
- Environmental Pollution as a Risk Factor in Testicular Tumour Development: Focus on the Interaction between Bisphenol A and the Associated Immune Response.International journal of environmental research and public health · 2019Article
- Bisphenol A alteration of type 1 diabetes in non-obese diabetic (NOD) female mice is dependent on window of exposure.Archives of toxicology · 2019Article
- BPA Alters Estrogen Receptor Expression in the Heart After Viral Infection Activating Cardiac Mast Cells and T Cells Leading to Perimyocarditis and Fibrosis.Frontiers in endocrinology · 2019Article
- Article
- Immune System: An Emerging Player in Mediating Effects of Endocrine Disruptors on Metabolic Health.Endocrinology · 2018Review
- Prenatal exposure to bisphenol A and risk of allergic diseases in early life.Pediatric research · 2017Article
- Gestational bisphenol-A exposure lowers the threshold for autoimmunity in a model of multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of prenatal exposure to bisphenol A (BPA) on the immune system in mice was investigated. Virgin female mice were fed varying doses of BPA, on a daily basis, over a period of 18 days commencing on the day of pairing with stud males (day 0). On day 77, their male offspring of 8 weeks were immunized with hen egg lysozyme (HEL). Three weeks later, anti-HEL immunoglobulin G (IgG) in sera, and proliferative responses of spleen cells to the antigen, were measured. Anti-HEL IgG2a and interferon-gamma (IFN-gamma), secreted from splenic lymphocytes, were measured as indicators of T helper 1 (Th1) immune responses, while anti-HEL IgG1 and interleukin-4 (IL-4) were measured as indicators of Th2 responses. The results showed that fetal exposure to BPA was followed by significant increases in anti-HEL IgG as well as antigen-specific cell proliferation. Both Th1 responses (including anti-HEL IgG2a and IFN-gamma production) and Th2 responses (including anti-HEL IgG1 and IL-4 production) were augmented by prenatal exposure to BPA, although the augmentation of Th1 responses appeared to be greater than that of Th2 responses. Two-colour flow cytometric analysis showed that mice exposed prenatally to BPA had 29% and 100% more splenic CD3(+) CD4(+) and CD3(+) CD8(+) cells, respectively, than control animals. Similar results were obtained from females whose mothers had consumed BPA during pregnancy. These results suggest that prenatal exposure to BPA may result in the up-regulation of immune responses, especially Th1 responses, in adulthood.
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Registered trials
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