ArticleOncogene2004
Absence of p21WAF1 cooperates with c-myc in bypassing Ras-induced senescence and enhances oncogenic cooperation.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Recent Advances in the Role of Autophagy in Endocrine-Dependent Tumors.Endocrine reviews · 2023Review
- Cellular senescence in neuroblastoma.British journal of cancer · 2022Review
- Establishment of a Novel PDX Mouse Model and Evaluation of the Tumor Suppression Efficacy of Bortezomib Against Liposarcoma.Translational oncology · 2019Article
- NAMPT overexpression induces cancer stemness and defines a novel tumor signature for glioma prognosis.Oncotarget · 2017Article
- Article
- Therapeutic targeting of replicative immortality.Seminars in cancer biology · 2015Review
- Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA.Oncotarget · 2015Article
- Disruptive chemicals, senescence and immortality.Carcinogenesis · 2015Review
- Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis.Journal of the National Cancer Institute · 2015Article
- Exploiting tumor cell senescence in anticancer therapy.BMB reports · 2014Review
- MAP17 and SGLT1 protein expression levels as prognostic markers for cervical tumor patient survival.PloS one · 2013Article
- Article
- Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21.Gastroenterology · 2011Article
- The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc.Journal of molecular medicine (Berlin, Germany) · 2011Article
- Cellular senescence as a target in cancer control.Journal of aging research · 2010Article
- HdmX overexpression inhibits oncogene induced cellular senescence.Cell cycle (Georgetown, Tex.) · 2010Article
- Inhibiting PI3K as a therapeutic strategy against cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2009Review
- p21 in cancer: intricate networks and multiple activities.Nature reviews. Cancer · 2009Review
- Article
- Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous mice.Experimental and molecular pathology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The absence of p21waf1 combined with an ectopic expression of c-myc prevents ras-induced senescence in mouse embryo fibroblasts. Extension of lifespan after c-myc transduction into p21-null cells was followed at later passages by apoptosis of a large fraction of c-myc-overexpressing p21-null cells. This apoptotic effect could be overridden by inactivation of the p53 tumor suppressor or oncogenic ras expression. Ras-induced inhibition of apoptosis is mediated by PI3K activation. These results suggest a functional relationship between ras and myc that may explain their oncogenic cooperation. The number of foci formed by myc+ras increased cooperatively in the absence of p21waf1. Thus, the reciprocal cooperation between myc and ras in a p21-null background during cellular immortalization lead to increased oncogenic cooperation between ras and myc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.