ArticleOncogene2004
Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
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- Identification of biomarkers for the diagnosis of type 2 diabetes mellitus with metabolic associated fatty liver disease by bioinformatics analysis and experimental validation.Frontiers in endocrinology · 2025Article
- Generation and characterization of two immortalized dermal fibroblast cell lines from the spiny mouse (Acomys).PloS one · 2023Article
- In Vivo Skin Regeneration and Wound Healing Using Cell Micro-Transplantation.Pharmaceutics · 2022Article
- SerpinB2 Regulates Immune Response in Kidney Injury and Aging.Journal of the American Society of Nephrology : JASN · 2020Article
- Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity.Cell cycle (Georgetown, Tex.) · 2014Article
- Comparative analysis of gene expression data reveals novel targets of senescence-associated microRNAs.PloS one · 2014Article
- Regulation of senescence in cancer and aging.Journal of aging research · 2011Article
- The senescence-associated secretory phenotype: the dark side of tumor suppression.Annual review of pathology · 2010Review
- Critical pathways in cellular senescence and immortalization revealed by gene expression profiling.Oncogene · 2008Review
- Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized.Molecular cancer · 2007Article
- Stem cells, senescence, neosis and self-renewal in cancer.Cancer cell international · 2006Article
- Effects of threshold choice on biological conclusions reached during analysis of gene expression by DNA microarrays.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The expression signature of in vitro senescence resembles mouse but not human aging.Genome biology · 2005Article
- Smurf2 up-regulation activates telomere-dependent senescence.Genes & development · 2004Article
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Telomere shortening in populations of human mammary epithelial cells (HMECs) that survive early replicative arrest (M0) by the inactivation of p16(INK4A) during cell culture on plastic dishes leads to a state of permanent replicative arrest termed senescence. While culture of HMECs on feeder layers abrogates M0 and p16(INK4A) inactivation, progressive telomere attrition in these cells also eventually results in permanent replicative arrest. Expression of telomerase prevents both senescence on plastic (S-P) and senescence on feeder layers (S-FL) in HMECs, as it does also in cultured primary human fibroblasts. We report here that the gene expression profiles of senescence in HMECs of the same lineage maintained under different culture conditions showed surprisingly little commonality. Moreover, neither of these senescence-associated profiles in HMECs resembles the profile for senescence in human fibroblasts. These results indicate that senescence-associated alterations in gene expression resulting from telomere attrition are affected by culture conditions as well as by cell origins, and argue that replicative senescence at the molecular level is a diverse rather than unique cellular process.
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