ArticleOncogene2004
p14ARF is a component of the p53 response following ionizing irradiation of normal human fibroblasts.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Complex p53 dynamics regulated by miR-125b in cellular responses to reactive oxidative stress and DNA damage.Briefings in bioinformatics · 2024Article
- The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence.Nucleic acids research · 2024Article
- Article
- Review
- Pinning Control for the p53-Mdm2 Network Dynamics Regulated by p14ARF.Frontiers in physiology · 2020Article
- Article
- Epigenetics in radiation-induced fibrosis.Oncogene · 2015Review
- Cellular senescence: a hitchhiker's guide.Human cell · 2015Review
- Bifurcation in Cell Cycle Dynamics Regulated by p53.PloS one · 2015Article
- ARF induction in response to DNA strand breaks is regulated by PARP1.Nucleic acids research · 2014Article
- Mammalian base excision repair: the forgotten archangel.Nucleic acids research · 2013Review
- Twilight effects of low doses of ionizing radiation on cellular systems: a bird's eye view on current concepts and research.Medical oncology (Northwood, London, England) · 2010Review
- ARF stimulates XPC to trigger nucleotide excision repair by regulating the repressor complex of E2F4.EMBO reports · 2009Article
- Article
- Explaining oscillations and variability in the p53-Mdm2 system.BMC systems biology · 2008Article
- DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer.Journal of molecular histology · 2006Review
- p53-induced apoptosis occurs in the absence of p14(ARF) in malignant pleural mesothelioma.Neoplasia (New York, N.Y.) · 2006Article
- p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress.Molecular and cellular biology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ionizing radiation leads to rapid stabilization and activation of the p53 tumor suppressor. Previous reports demonstrate that murine p19ARF cooperates with p53 in the cellular response to gamma irradiation. Here, we show that endogenous ARF sequentially interacts with p53 and MDM2 following irradiation of primary human and mouse embryonic fibroblasts. Shortly after irradiation, p14ARF binds p53 independently of MDM2. As nuclear pools of p53 decline, endogenous p14ARF co-immunoprecipitates with MDM2 and is localized within the nucleolus. Interestingly, p14ARF nucleolar localization during this response is abrogated in cells lacking functional p53. Taken together, our data suggest that human and murine ARF contribute to the mammalian DNA damage response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.