Evidence map›Paper›PMID 15194805›Full record

ArticleJournal of virology2004

Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypes.

Manish Sagar, Erin Kirkegaard, E Michelle Long, Connie Celum, Susan Buchbinder, Eric S Daar, Julie Overbaugh

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 70 citations in OpenAlex.

  1. Trial
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  16. Article
  17. HIV transmission.Cold Spring Harbor perspectives in medicine · 2012
    Review
  18. Article
  19. The Antibody Response against HIV-1.Cold Spring Harbor perspectives in medicine · 2012
    Review
  20. Role of donor genital tract HIV-1 diversity in the transmission bottleneck.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Manish SagarDivision of Human Biology, Fred Hutchinson Cancer Research Center, and Department of Medicine, University of Washington, Seattle, USA.
Erin Kirkegaard
E Michelle Long
Connie Celum
Susan Buchbinder
Eric S Daar
Julie Overbaugh
University of Washington · USCancer Research Center · USSan Francisco Department of Public Health · USUCLA Medical Center · US

Funding

ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI WANG, CHRISTINA C. · 1985 to 2011
$74.2M
Southern California Primary Infection ProgramU01AI043638 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RICHMAN, DOUGLAS D · 1998 to 2010
$21.3M
EARLY INFECTION IN WOMEN EXPOSED MUCOSALLY TO HIV-1R37AI038518 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI OVERBAUGH, JULIE M. · 1999 to 2019
$12.9M
The role of viral diversity in HIV-1 drug resistanceK08AI052759 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SAGAR, MANISH · 2002 to 2006
$593k
NCRR NIH HHS M01 RR000425NCRR NIH HHS RR00425NIAID NIH HHS AI43638NIAID NIH HHS AI52759NIAID NIH HHS K08 AI052759NIAID NIH HHS R37 AI038518NIAID NIH HHS U01 AI043638PHS HHS I38518
6 · The paper itself

Abstract

African women frequently acquire several genetically distinct human immunodeficiency virus type 1 (HIV-1) variants from a heterosexual partner, whereas the acquisition of multiple variants appears to be rare in men. To determine whether newly infected individuals in other risk groups acquire genetically diverse viruses, we examined the viral envelope sequences in plasma samples from 13 women and 4 men from the United States infected with subtype B viruses and 10 men from Kenya infected with non-subtype B viruses. HIV-1 envelope sequences differed by more than 2% in three U.S. women, one U.S. man, and one Kenyan man near the time of seroconversion. These findings suggest that early HIV-1 genetic diversity is not exclusive to women from Africa or to infection with any particular HIV-1 subtype.

Indexed as

Genetic VariationFemaleGene Products, envHeteroduplex AnalysisHIV-1HIV InfectionsHumansKenyaMaleMolecular Sequence DataRisk FactorsSequence Analysis, DNAUnited StatesGene Products, env

Identifiers

PMID15194805
PMCPMC421693
OpenAlexW2072752981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.