ArticleJournal of virology2004
Modulation of p53 cellular function and cell death by African swine fever virus.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Transcriptome signatures of host tissue infected with African swine fever virus reveal differential expression of associated oncogenes.Archives of virology · 2024Review
- Functional Landscape of African Swine Fever Virus-Host and Virus-Virus Protein Interactions.Viruses · 2023Review
- African Swine Fever Virus Host-Pathogen Interactions.Sub-cellular biochemistry · 2023Article
- African Swine Fever Virus: A Review.Life (Basel, Switzerland) · 2022Review
- Mandarin Fish (Siniperca chuatsi) p53 Regulates Glutaminolysis Induced by Virus via the p53/miR145-5p/c-Myc Pathway in Chinese Perch Brain Cells.Microbiology spectrum · 2022Article
- Regulation and Evasion of Host Immune Response by African Swine Fever Virus.Frontiers in microbiology · 2021Review
- African Swine Fever Virus Induces STAT1 and STAT2 Degradation to Counteract IFN-I Signaling.Frontiers in microbiology · 2021Article
- PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer.Science advances · 2019Article
- Targeting of PP2Cδ By a Small Molecule C23 Inhibits High Glucose-Induced Breast Cancer ProgressionAntioxidants & redox signaling · 2019Article
- African swine fever virus evasion of host defences.Virus research · 2019Review
- Comparative proteomic analysis reveals different responses in porcine lymph nodes to virulent and attenuated homologous African swine fever virus strains.Veterinary research · 2018Article
- Characterization of the African Swine Fever Virus Decapping Enzyme during Infection.Journal of virology · 2017Article
- Phenotyping and susceptibility of established porcine cells lines to African Swine Fever Virus infection and viral production.Scientific reports · 2017Article
- Investigations of Pro- and Anti-Apoptotic Factors Affecting African Swine Fever Virus Replication and Pathogenesis.Viruses · 2017Review
- p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis.The American journal of pathology · 2017Article
- Alterations of Nuclear Architecture and Epigenetic Signatures during African Swine Fever Virus Infection.Viruses · 2015Article
- African swine fever virus-cell interactions: from virus entry to cell survival.Virus research · 2013Review
- African swine fever virus uses macropinocytosis to enter host cells.PLoS pathogens · 2012Article
- Disruption of nuclear organization during the initial phase of African swine fever virus infection.Journal of virology · 2011Article
- Regulation of host translational machinery by African swine fever virus.PLoS pathogens · 2009Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modulation of the activity of tumor suppressor p53 is a key event in the replication of many viruses. We have studied the function of p53 in African swine fever virus (ASFV) infection by determining the expression and activity of this transcription factor in infected cells. p53 levels are increased at early times of infection and are maintained throughout the infectious cycle. The protein is transcriptionally active, stabilized by phosphorylation, and localized in the nucleus. p53 induces the expression of p21 and Mdm2. Strikingly, these two proteins are located at the cytoplasmic virus factories. The retention of Mdm2 at the factory may represent a viral mechanism to prevent p53 inactivation by the protein. The expression of apoptotic proteins, such as Bax or active caspase-3, is also increased following ASFV infection, although the increase in caspase-3 does not appear to be, at least exclusively, p53 dependent. Bax probably plays a role in the induction of apoptosis in the infected cells, as suggested by the release of cytochrome c from the mitochondria. The significance of p21 induction and localization is discussed in relation to the shutoff of cellular DNA synthesis that is observed in ASFV-infected cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.