ArticleJournal of virology2004
The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Simultaneous expression of three G genotypes of VP7 proteins in a recombinant porcine rotavirus confers protective immunity against multiple rotavirus infections.Journal of virology · 2026Article
- Generation of G9 genotype porcine rotavirus using reverse genetics system and its application for antiviral screen and vaccine development.Virologica Sinica · 2026Article
- A novel glycoform of the rotavirus outer capsid protein VP7 is secreted from polarized cells and activates innate immune cells.Journal of virology · 2026Article
- Dendritic cell expression of MyD88 is required for rotavirus-induced B cell activation.Journal of virology · 2025Article
- Lack of evidence of rotavirus-dependent molecular mimicry as a trigger of coeliac disease.Clinical and experimental immunology · 2016Article
- Comparison of probiotic lactobacilli and bifidobacteria effects, immune responses and rotavirus vaccines and infection in different host species.Veterinary immunology and immunopathology · 2016Review
- The improvement effects of edible bird's nest on proliferation and activation of B lymphocyte and its antagonistic effects on immunosuppression induced by cyclophosphamide.Drug design, development and therapy · 2016Article
- Rotavirus activates lymphocytes from non-obese diabetic mice by triggering toll-like receptor 7 signaling and interferon production in plasmacytoid dendritic cells.PLoS pathogens · 2014Article
- Plasmacytoid dendritic cells promote rotavirus-induced human and murine B cell responses.The Journal of clinical investigation · 2013Article
- Division of labor during primary humoral immunity.Immunologic research · 2013Review
- Host response to probiotics determined by nutritional status of rotavirus-infected neonatal mice.Journal of pediatric gastroenterology and nutrition · 2012Article
- Recombinant outer capsid glycoprotein (VP7) of rotavirus expressed in insect cells induces neutralizing antibodies in rabbits.Iranian journal of public health · 2012Article
- In silico study of rotavirus VP7 surface accessible conserved regions for antiviral drug/vaccine design.PloS one · 2012Article
- Innate immune responses to human rotavirus in the neonatal gnotobiotic piglet disease model.Immunology · 2010Article
- Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response.The Journal of experimental medicine · 2010Article
- Rotavirus differentially infects and polyclonally stimulates human B cells depending on their differentiation state and tissue of origin.Journal of virology · 2010Article
- Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signaling.Journal of virology · 2008Article
- C-reactive protein inhibits cholesterol efflux from human macrophage-derived foam cells.Arteriosclerosis, thrombosis, and vascular biology · 2008Article
- The isolator piglet: a model for studying the development of adaptive immunity.Immunologic research · 2007Review
- Rotavirus infection enhances lipopolysaccharide-induced intussusception in a mouse model.Journal of virology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The early response to a homologous rotavirus infection in mice includes a T-cell-independent increase in the number of activated B lymphocytes in the Peyer's patches. The mechanism of this activation has not been previously determined. Since rotavirus has a repetitively arranged triple-layered capsid and repetitively arranged antigens can induce activation of B cells, one or more of the capsid proteins could be responsible for the initial activation of B cells during infection. To address this question, we assessed the ability of rotavirus and virus-like particles to induce B-cell activation in vivo and in vitro. Using infectious rotavirus, inactivated rotavirus, noninfectious but replication-competent virus, and virus-like particles, we determined that neither infectivity nor RNA was necessary for B-cell activation but the presence of the rotavirus outer capsid protein, VP7, was sufficient for murine B-cell activation. Preincubation of the virus with neutralizing VP7 antibodies inhibited B-cell activation. Polymyxin B treatment and boiling of the virus preparation were performed, which ruled out possible lipopolysaccharide contamination as the source of activation and confirmed that the structural conformation of VP7 is important for B-cell activation. These findings indicate that the structure and conformation of the outer capsid protein, VP7, initiate intestinal B-cell activation during rotavirus infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.