ArticleJournal of virology2004
Murine cytomegalovirus with a transposon insertional mutation at open reading frame m155 is deficient in growth and virulence in mice.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- An Oral Vaccine Derived from AttenuatedVaccines · 2026Article
- An OralPathogens (Basel, Switzerland) · 2025Article
- Antiviral Immune Responses Against Murine Cytomegalovirus Induced by an OralMicroorganisms · 2025Article
- Oral Vaccination with AttenuatedPathogens (Basel, Switzerland) · 2025Article
- Article
- Article
- Engineered RNase P Ribozymes Effectively Inhibit the Infection of Murine Cytomegalovirus in Animals.Theranostics · 2018Article
- Effective inhibition of cytomegalovirus infection by external guide sequences in mice.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The mouse cytomegalovirus glycoprotein m155 inhibits CD40 expression and restricts CD4 T cell responses.Journal of virology · 2011Article
- Oral delivery of RNase P ribozymes by Salmonella inhibits viral infection in mice.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Feeling manipulated: cytomegalovirus immune manipulation.Virology journal · 2009Article
- Effective inhibition in animals of viral pathogenesis by a ribozyme derived from RNase P catalytic RNA.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Characterization of the murine cytomegalovirus m136 gene.Virus genes · 2007Article
- Murine cytomegalovirus encodes a stable intron that facilitates persistent replication in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18.The Journal of general virology · 2005Article
- Selective down-regulation of the NKG2D ligand H60 by mouse cytomegalovirus m155 glycoprotein.Journal of virology · 2005Article
- The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions.The Journal of experimental medicine · 2004Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
A pool of murine cytomegalovirus (MCMV) mutants was previously generated by using a Tn3-based transposon mutagenesis approach (X. Zhan, M. Lee, J. Xiao, and F. Liu, J. Virol. 74:7411-7421, 2000). In this study, one of the MCMV mutants, Rvm155, which contained the transposon insertion in open reading frame m155, was characterized in vitro for its replication in tissue culture and in vivo for its growth and virulence in immunodeficient SCID mice. Compared to the wild-type strain and a rescued virus that restored the m155 region, the mutant is significantly deficient in growth in many organs of the infected animals. At 21 days postinfection the titers of Rvm155 in the salivary glands, lungs, spleens, livers, and kidneys of the intraperitoneally infected SCID mice were lower than the titers of the wild-type virus and the rescued virus by 50-, 1,000-, 500-, 100-, and 500-fold, respectively. Moreover, the viral mutant was attenuated in killing the SCID mice, as none of the SCID mice that were intraperitoneally infected with Rvm155 died until 38 days postinfection while all the animals infected with the wild-type and rescued viruses died at 27 days postinfection. Our results provide the first direct evidence that a disruption of m155 expression leads to attenuation of viral virulence and growth in animals. Moreover, these results suggest that m155 is a viral determinant for optimal MCMV growth and virulence in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.