ArticleJournal of virology2004
Critical role of CD4 T cells in an antibody-independent mechanism of vaccination against gammaherpesvirus latency.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Indirect CD4Journal of virology · 2024Article
- Immune Control ofViral immunology · 2020Article
- LXR Alpha Restricts Gammaherpesvirus Reactivation from Latently Infected Peritoneal Cells.Journal of virology · 2019Article
- Type I Interferon Signaling to Dendritic Cells Limits Murid Herpesvirus 4 Spread from the Olfactory Epithelium.Journal of virology · 2017Article
- CD4 T cells mediate killing during persistent gammaherpesvirus 68 infection.Journal of virology · 2009Article
- Immune mechanisms responsible for vaccination against and clearance of mucosal and lymphatic norovirus infection.PLoS pathogens · 2008Article
- Antibody is critical for the clearance of murine norovirus infection.Journal of virology · 2008Article
- The relative contribution of antibody and CD8+ T cells to vaccine immunity against West Nile encephalitis virus.Vaccine · 2008Article
- Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help.The Journal of experimental medicine · 2006Article
- Antibody-independent control of gamma-herpesvirus latency via B cell induction of anti-viral T cell responses.PLoS pathogens · 2006Article
- Effective control of chronic gamma-herpesvirus infection by unconventional MHC Class Ia-independent CD8 T cells.PLoS pathogens · 2006Article
- CD8+ T cells require perforin to clear West Nile virus from infected neurons.Journal of virology · 2006Article
- Alpha/beta interferons regulate murine gammaherpesvirus latent gene expression and reactivation from latency.Journal of virology · 2005Article
- An optimized CD8+ T-cell response controls productive and latent gammaherpesvirus infection.Journal of virology · 2005Article
- Immune regulation of viral infection and vice versa.Immunologic research · 2005Review
- An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection.Journal of virology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have previously demonstrated that it is possible to effectively vaccinate against long-term murine gammaherpesvirus 68 (gamma HV68) latency by using a reactivation-deficient virus as a vaccine (S. A. Tibbetts, J. S. McClellan, S. Gangappa, S. H. Speck, and H. W. Virgin IV, J. Virol. 77:2522-2529, 2003). Immune antibody was capable of recapitulating aspects of this vaccination. This led us to determine whether antibody is required for vaccination against latency. Using mice lacking antigen-specific antibody responses, we demonstrate here that antibody and B cells are not required for vaccination against latency. We also show that surveillance of latent infection in normal animals depends on CD4 and CD8 T cells, suggesting that T cells might be capable of preventing the establishment of latency. In the absence of an antibody response, CD4 T cells but not CD8 T cells are required for effective vaccination against latency in peritoneal cells, while either CD4 or CD8 T cells can prevent the establishment of splenic latency. Therefore, CD4 T cells play a critical role in immune surveillance of gammaherpesvirus latency and can mediate vaccination against latency in the absence of antibody responses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.