ArticleJournal of virology2004
An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
36 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- The amplitude of gammaherpesvirus lytic replication dictates adaptive immune activation: Potential implications for KSHV LANA in immune evasion.bioRxiv : the preprint server for biology · 2026Article
- Immunological Control of Herpes Simplex Virus Type 1 Infection: A Non-Thermal Plasma-Based Approach.Viruses · 2025Review
- T Cell-Intrinsic Interferon Regulatory Factor 1 Expression Suppresses Differentiation of CD4Journal of virology · 2021Article
- Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation.PLoS pathogens · 2020Article
- Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection.Scientific reports · 2020Article
- LXR Alpha Restricts Gammaherpesvirus Reactivation from Latently Infected Peritoneal Cells.Journal of virology · 2019Article
- Molecular Basis of the Differentiation and Function of Virus Specific Follicular Helper CD4Frontiers in immunology · 2019Review
- Advances in the Characterization of the T-Cell Response to Human Herpesvirus-6.Frontiers in immunology · 2018Review
- Functional heterogeneity in the CD4+ T cell response to murine γ-herpesvirus 68.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- CD4 CTL: living up to the challenge.Seminars in immunology · 2013Review
- CD4 and CD8 T cells directly recognize murine gammaherpesvirus 68-immortalized cells and prevent tumor outgrowth.Journal of virology · 2013Article
- Herpesviruses placating the unwilling host: manipulation of the MHC class II antigen presentation pathway.Viruses · 2012Review
- Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Specific mutation of a gammaherpesvirus-expressed antigen in response to CD8 T cell selection in vivo.Journal of virology · 2012Article
- Expanding roles for CD4⁺ T cells in immunity to viruses.Nature reviews. Immunology · 2012Review
- Immunotherapy of human papilloma virus induced disease.The open virology journal · 2012Article
- Malignant catarrhal fever induced by Alcelaphine herpesvirus 1 is characterized by an expansion of activated CD3+CD8+CD4- T cells expressing a cytotoxic phenotype in both lymphoid and non-lymphoid tissues.Veterinary research · 2011Article
- Induction of TGF-beta 1, not regulatory T cells, impairs antiviral immunity in the lung following bone marrow transplant.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Persistent gamma-herpesvirus infection induces a CD4 T cell response containing functionally distinct effector populations.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
CD4 T cells are important for control of infection with murine gammaherpesvirus 68 (gamma HV68), but it is not known whether CD4 T cells function via provision of help to other lymphocyte subsets, such as B cells and CD8 T cells, or have an independent antiviral function. Moreover, under conditions of natural infection, the CD4 T-cell response is not sufficient to eliminate infection. To determine the functional capacities of CD4 T cells under optimal or near-optimal conditions and to determine whether CD4 T cells can control gamma HV68 infection in the absence of CD8 T cells or B cells, we studied the effect of ovalbumin (OVA)-specific CD4 T cells on infection with a recombinant gamma HV68 that expresses OVA. OVA-specific CD4 T cells limited acute gamma HV68 replication and prolonged the life of infected T-cell receptor-transgenic RAG (DO.11.10/RAG) mice, demonstrating CD4 T-cell antiviral activity, independent of CD8 T cells and B cells. Despite CD4 T-cell-mediated control of acute infection, latent infection was established in DO.11.10/RAG mice. However, OVA-specific CD4 T cells reduced the frequency of latently infected cells both early (16 days postinfection) and late (42 days postinfection) after infection of mice containing CD8 T cells and B cells (DO.11.10 mice). These results show that OVA-specific CD4 T cells have B-cell and CD8 T-cell-independent antiviral functions in the control of acute infection and can, in the absence of preexisting CD8 T-cell or B-cell immunity, inhibit the establishment of gammaherpesvirus latency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.