ArticleThe Journal of physiology2004
An analysis of inhibitory junction potentials in the guinea-pig proximal colon.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Etiology of Colitis-Complex Diarrhea in Growing Pigs: A Review.Animals : an open access journal from MDPI · 2021Review
- Nitric oxide and its role as a non-adrenergic, non-cholinergic inhibitory neurotransmitter in the gastrointestinal tract.British journal of pharmacology · 2019Review
- Comparison of inhibitory neuromuscular transmission in the Cynomolgus monkey IAS and rectum: special emphasis on differences in purinergic transmission.The Journal of physiology · 2018Article
- Enteric Inhibitory Neurotransmission, Starting Down Under.Advances in experimental medicine and biology · 2016Review
- Colligative Property of ATP: Implications for Enteric Purinergic Neuromuscular Neurotransmission.Frontiers in physiology · 2016Article
- The purinergic neurotransmitter revisited: a single substance or multiple players?Pharmacology & therapeutics · 2014Review
- The significance of interstitial cells in neurogastroenterology.Journal of neurogastroenterology and motility · 2014Article
- Purinergic signalling in the gastrointestinal tract and related organs in health and disease.Purinergic signalling · 2014Review
- Stretch-dependent sensitization of post-junctional neural effectors in colonic muscles.Neurogastroenterology and motility · 2013Article
- Ionic conductances regulating the excitability of colonic smooth muscles.Neurogastroenterology and motility · 2012Review
- Adenosine 5-diphosphate-ribose is a neural regulator in primate and murine large intestine along with β-NAD(+).The Journal of physiology · 2012Article
- Neuroeffector apparatus in gastrointestinal smooth muscle organs.The Journal of physiology · 2010Review
- Interstitial cells of Cajal generate spontaneous transient depolarizations in the rat gastric fundus.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Purinergic mechanisms in the control of gastrointestinal motility.Purinergic signalling · 2008Article
- Block of inhibitory junction potentials and TREK-1 channels in murine colon by Ca2+ store-active drugs.The Journal of physiology · 2008Article
- Role of K(+) channels in the regulation of electrical spontaneous activity of the mouse small intestine.Pflugers Archiv : European journal of physiology · 2007Article
- Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular recordings were made from either sheets or isolated bundles of the circular muscle layer of guinea-pig proximal colon and the responses evoked by stimulating inhibitory nerve fibres were analysed. Inhibitory junction potentials (IJPs), evoked by single stimuli, had two components which could be separated on their pharmacological and temporal characteristics and their voltage sensitivities. The initial component, which was abolished by apamin and reduced in amplitude by pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS), had a brief time course: its amplitude was changed when the external concentration of potassium ions ([K+](o)) was changed. The second component of the IJP had a slower onset than the first component, was abolished by l-nitroarginine (NOLA) and oxadiazolo quinoxalin-1-one (ODQ), an inhibitor of soluble guanylate cyclase: its amplitude was little affected by changing [K+](o) and was increased when the membrane potential of the circular layer was hyperpolarized. The observations suggest that the initial component of the IJP results from the release of ATP which triggers an increase in membrane conductance to K+ and that the second component results from the release of nitric oxide which suppresses a background inward current.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.