ArticleGut2004
Identification of a genetic marker of Helicobacter pylori strains involved in gastric extranodal marginal zone B cell lymphoma of the MALT-type.
Article in Gut, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Excision and transfer of an integrating and conjugative element in a bacterial species with high recombination efficiency.Scientific reports · 2019Article
- Gastric lymphoma: association with Helicobacter pylori outer membrane protein Q (HopQ) and cytotoxic-pathogenicity activity island (CPAI) genes.Epidemiology and infection · 2017Article
- Review
- Role of Plasticity Region Genes and cagE gene of cagPAI of Helicobacter pylori in Development of Gastrointestinal (GI) DiseasesAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Helicobacter pylori plasticity region genes are associated with the gastroduodenal diseases manifestation in India.Gut pathogens · 2016Article
- A comprehensive analysis of Helicobacter pylori plasticity zones reveals that they are integrating conjugative elements with intermediate integration specificity.BMC genomics · 2014Article
- Inflammatory cytokine and microRNA responses of primary human dendritic cells cultured with Helicobacter pylori strains.Frontiers in microbiology · 2013Article
- Role of Helicobacter pylori plasticity region genes in development of gastroduodenal diseases.Journal of clinical microbiology · 2012Article
- Complexomics study of two Helicobacter pylori strains of two pathological origins: potential targets for vaccine development and new insight in bacteria metabolism.Molecular & cellular proteomics : MCP · 2010Article
- From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma.BMC genomics · 2010Article
- Cytotoxic T cells in H. pylori-related gastric autoimmunity and gastric lymphoma.Journal of biomedicine & biotechnology · 2010Review
- Article
- Comparative genomics of Helicobacter pylori.World journal of gastroenterology · 2009Review
- Differences in genome content among Helicobacter pylori isolates from patients with gastritis, duodenal ulcer, or gastric cancer reveal novel disease-associated genes.Infection and immunity · 2009Article
- A variable gene in a conserved region of the Helicobacter pylori genome: isotopic gene replacement or rapid evolution?DNA research : an international journal for rapid publication of reports on genes and genomes · 2008Article
- Roles of the plasticity regions of Helicobacter pylori in gastroduodenal pathogenesis.Journal of medical microbiology · 2008Review
- Identification of markers for Helicobacter pylori strains isolated from children with peptic ulcer disease by suppressive subtractive hybridization.Infection and immunity · 2006Article
- Helicobacter pylori and gastroduodenal pathology: new threats of the old friend.Annals of clinical microbiology and antimicrobials · 2005Review
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsGastric extranodal marginal zone B cell lymphoma of the mucosa associated lymphoid tissue (MALT)-type (MZBL) is a rare complication of Helicobacter pylori infection. Currently, no bacterial factor has been associated with the development of this disease. Our aim was to identify genes associated with lymphoma development.
methodsWe used subtractive hybridisation as a tool for comparative genomics between H pylori strains isolated from a patient with gastric MZBL and from a patient with gastritis only.
resultsWhen gastric MZBL strains were compared with gastritis strains, two open reading frames (ORFs) were significantly associated with gastric MZBL: JHP950 (74.4% v 48.7%, respectively; p = 0.023) and JHP1462 (25.6% v 2.6%, respectively; p = 0.004). The prevalence of JHP950 was 48.8% (p = 0.024) in duodenal ulcer strains and 39.3% (p = 0.006) in gastric adenocarcinoma strains, which makes this ORF a specific marker for gastric MZBL strains. In contrast, the prevalence of JHP1462 was 16% (p = 0.545) and 35.7% (p = 0.429) in duodenal ulcer and adenocarcinoma strains, respectively. These ORFs were present in reference strain J99 but not in reference strain 26695. JHP950 is located in the plasticity zone whereas the other, JHP1462, is located outside. Both encode for H pylori putative proteins with unknown functions.
conclusionDespite its low prevalence, the ORF JHP1462 can be considered a candidate marker for H pylori strains involved in severe gastroduodenal diseases. In contrast, the ORF JHP950 has a high prevalence, and is the first candidate marker for strains giving rise to an increased risk of gastric MZBL strains. Further confirmation in other studies is needed.
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