ArticleThe Biochemical journal2004
Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation.
Article in The Biochemical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Vitamin A supplementation downregulatesAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
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- New insights and changing paradigms in the regulation of vitamin A metabolism in development.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Role of Retinoic Acid (RA) in Spermatogonial Differentiation.Biology of reproduction · 2016Review
- Vitamin A, cancer treatment and prevention: the new role of cellular retinol binding proteins.BioMed research international · 2015Review
- Genetic dissection of retinoid esterification and accumulation in the liver and adipose tissue.Journal of lipid research · 2014Article
- Increased unbound retinol-binding protein 4 concentration induces apoptosis through receptor-mediated signaling.The Journal of biological chemistry · 2012Article
- Short chain dehydrogenase/reductase rdhe2 is a novel retinol dehydrogenase essential for frog embryonic development.The Journal of biological chemistry · 2012Article
- Mammalian carotenoid-oxygenases: key players for carotenoid function and homeostasis.Biochimica et biophysica acta · 2012Review
- Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models.Biochimica et biophysica acta · 2012Review
- Physiological insights into all-trans-retinoic acid biosynthesis.Biochimica et biophysica acta · 2012Review
- Suppression of Stra8 expression in the mouse gonad by WIN 18,446.Biology of reproduction · 2011Article
- Retinol dehydrogenase 10 but not retinol/sterol dehydrogenase(s) regulates the expression of retinoic acid-responsive genes in human transgenic skin raft culture.The Journal of biological chemistry · 2011Article
- Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner.The Journal of biological chemistry · 2010Article
- Cellular retinol-binding protein type I (CRBP-I) regulates adipogenesis.Molecular and cellular biology · 2010Article
- The key role of vitamin A in spermatogenesis.The Journal of clinical investigation · 2010Review
- Review
- Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenase.The Journal of biological chemistry · 2008Article
- Retinoic acid regulation of the somitogenesis clock.Birth defects research. Part C, Embryo today : reviews · 2007Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Vitamin A homoeostasis requires the gene encoding cellular retinol-binding protein-1 (Crbp1) which stimulates conversion of retinol into retinyl esters that serve as a storage form of vitamin A. The gene encoding alcohol dehydrogenase-1 (Adh1) greatly facilitates degradative metabolism of excess retinol into retinoic acid to protect against toxic effects of high dietary vitamin A. Crbp1-/-/Adh1-/- double mutant mice were generated to explore whether the stimulatory effect of CRBP1 on retinyl ester formation is due to limitation of retinol oxidation by ADH1, and whether ADH1 limits retinyl ester formation by opposing CRBP1. Compared with wild-type mice, liver retinyl ester levels were greatly reduced in Crbp1-/- mice, but Adh1-/- mice exhibited a significant increase in liver retinyl esters. Importantly, relatively normal liver retinyl ester levels were restored in Crbp1-/-/Adh1-/- mice. During vitamin A deficiency, the additional loss of Adh1 completely prevented the excessive loss of liver retinyl esters observed in Crbp1-/- mice for the first 5 weeks of deficiency and greatly minimized this loss for up to 13 weeks. Crbp1-/- mice also exhibited increased metabolism of a dose of retinol into retinoic acid, and this increased metabolism was not observed in Crbp1-/-/Adh1-/- mice. Our findings suggest that opposing actions of CRBP1 and ADH1 enable a large fraction of liver retinol to remain esterified due to CRBP1 action, while continuously allowing some retinol to be oxidized to retinoic acid by ADH1 for degradative retinoid turnover under any dietary vitamin A conditions.
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