ArticleThe EMBO journal2004
Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT.
Article in The EMBO journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Vitamin C enhances cytotoxicity of CAR-and εTRuC-engineered γδ T cells and modulates CaFrontiers in immunology · 2026Article
- Biomolecular condensates in plant immunity.Cell host & microbe · 2025Review
- Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets.Signal transduction and targeted therapy · 2025Review
- Regulating the discriminatory response to antigen by T-cell receptor.Bioscience reports · 2022Review
- IL-23 signaling regulation of pro-inflammatory T-cell migration uncovered by phosphoproteomics.PLoS biology · 2020Article
- A Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling.Frontiers in immunology · 2018Article
- Negative feedback regulation of the ERK1/2 MAPK pathway.Cellular and molecular life sciences : CMLS · 2016Review
- The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.Science signaling · 2013Article
- Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.Trends in immunology · 2013Review
- Gene expression profile of the hippocampus of rats subjected to chronic immobilization stress.PloS one · 2013Article
- LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.Molecular cell · 2012Article
- Differential requirement of RasGRP1 for γδ T cell development and activation.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development.The Journal of biological chemistry · 2012Article
- A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity.Immunologic research · 2011Review
- T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Regulation of lymphocyte development and activation by the LAT family of adapter proteins.Immunological reviews · 2009Review
- Tregs utilize beta-galactoside-binding protein to transiently inhibit PI3K/p21ras activity of human CD8+ T cells to block their TCR-mediated ERK activity and proliferation.Brain, behavior, and immunity · 2009Article
- A global transcriptional view of apoptosis in human T-cell activation.BMC medical genomics · 2008Article
- Diacylglycerol kinases in immune cell function and self-tolerance.Immunological reviews · 2008Review
- A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.The Journal of experimental medicine · 2007Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitogen-activated protein kinase (MAPK) cascades are involved in a variety of cellular responses including proliferation, differentiation, and apoptosis. We have developed an expression screening method to detect in vivo substrates of MAPKs in mammalian cells, and identified a membrane protein, linker for activation of T cells (LAT), as an MAPK target. LAT, an adapter protein essential for T-cell signaling, is phosphorylated at its Thr 155 by ERK in response to T-cell receptor stimulation. Thr 155 phosphorylation reduces the ability of LAT to recruit PLCgamma1 and SLP76, leading to attenuation of subsequent downstream events such as [Ca2+]i mobilization and activation of the ERK pathway. Our data reveal a new role for MAPKs in a negative feedback loop in T-cell activation via threonine phosphorylation of LAT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.