ReviewCurrent atherosclerosis reports2004
Therapeutic time window of thrombolytic therapy following stroke.
Review in Current atherosclerosis reports, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Circadian clock regulation of hemostasis: a systematic review of molecular pathways.Research and practice in thrombosis and haemostasis · 2026Pooled it
- Pericyte derivation and transplantation for blood-CNS barrier reconstitution in CNS disorders.IBRO neuroscience reports · 2024Article
- Clinical review of stroke care at National District Hospital, Bloemfontein.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2023Article
- New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke.Frontiers in pharmacology · 2022Review
- Mechanical Thrombectomy by a Direct Aspiration First Pass Technique (ADAPT) in Ischemic Stroke: Results of Monocentric Study Based on Multimodal CT Patient Selection.Stroke research and treatment · 2018Article
- Krüpple-like factors in the central nervous system: novel mediators in stroke.Metabolic brain disease · 2015Review
- Angiogenesis-regulating microRNAs and Ischemic Stroke.Current vascular pharmacology · 2015Review
- 64-Slice spiral CT perfusion combined with vascular imaging of acute ischemic stroke for assessment of infarct core and penumbra.Experimental and therapeutic medicine · 2013Article
- Comparison of CT and MR imaging in ischemic stroke.Insights into imaging · 2012Article
- Standardization of Stroke Perfusion CT for Reperfusion Therapy.Translational stroke research · 2012Article
- Article
- Stroke imaging research road map.Neuroimaging clinics of North America · 2011Review
- Neuroimaging of cerebral ischemia and infarction.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2011Review
- Imaging of acute ischemic stroke.Neuroimaging clinics of North America · 2010Article
- Brain Attack : Time to Act Now.Medical journal, Armed Forces India · 2009Article
- Heart-fatty acid-binding protein as a marker for early detection of acute myocardial infarction and stroke.Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Stroke is the third leading cause of death after myocardial infarction and cancer and the leading cause of permanent disability and of disability-adjusted loss of independent life-years in Western countries. Thrombolysis is the treatment of choice for acute stroke within 3 hours after symptom onset. Treatment beyond the 3-hour time window has not been shown to be effective in any single trial; however, meta-analyses suggest a somewhat less but still significant effect within 3 to 6 hours after stroke. It seems reasonable to apply improved selection criteria that would allow one to differentiate patients with a relevant indication for thrombolytic therapy from those who do not have one. We present an overview of a diagnostic approach to acute stroke management that allows the clinician to individualize patient management based on pathophysiologic reasoning and not rigid time windows established by randomized controlled trials. Therefore, this review concentrates on giving the reader an integrated knowledge of the current status of thrombolytic therapy in stroke and then develops a treatment algorithm based on pathophysiologic information rendered by a multiparametric stroke magnetic resonance imaging protocol.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.