ReviewJournal of inherited metabolic disease2004
Retrotransposon-derived elements in the mammalian genome: a potential source of disease.
Review in Journal of inherited metabolic disease, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- Sex-biased Expression of Genes and Transposable Elements in Hybrids from Drosophila mojavensis and Drosophila arizonae.Genome biology and evolution · 2026Article
- Retrotransposon: an insight into neurological disorders from perspectives of neurodevelopment and aging.Translational neurodegeneration · 2025Review
- Developmental origins of diabetes mellitus: Environmental epigenomics and emerging patterns.Journal of diabetes · 2023Review
- Mouse germ line mutations due to retrotransposon insertions.Mobile DNA · 2019Review
- Genome-wide evolutionary and functional analysis of the Equine Repetitive Element 1: an insertion in the myostatin promoter affects gene expression.BMC genetics · 2015Article
- The Triform algorithm: improved sensitivity and specificity in ChIP-Seq peak finding.BMC bioinformatics · 2012Article
- Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene.The Journal of biological chemistry · 2012Article
- Genetic variation and its role in malignancy.International journal of biomedical science : IJBS · 2011Article
- Recent amplification of the kangaroo endogenous retrovirus, KERV, limited to the centromere.Journal of virology · 2011Article
- Parasites or cohabitants: cruel omnipresent usurpers or creative "éminences grises"?Journal of parasitology research · 2011Article
- Repeat-element driven activation of proto-oncogenes in human malignancies.Cell cycle (Georgetown, Tex.) · 2010Article
- Adaptation to diverse nitrogen-limited environments by deletion or extrachromosomal element formation of the GAP1 locus.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Epigenetic effects of endocrine-disrupting chemicals on female reproduction: an ovarian perspective.Frontiers in neuroendocrinology · 2010Review
- Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma.Nature medicine · 2010Article
- The imprinted retrotransposon-like gene PEG11 (RTL1) is expressed as a full-length protein in skeletal muscle from Callipyge sheep.PloS one · 2010Article
- MouseIndelDB: a database integrating genomic indel polymorphisms that distinguish mouse strains.Nucleic acids research · 2010Article
- Article
- RNA expression microarray analysis in mouse prospermatogonia: identification of candidate epigenetic modifiers.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Conserved themes in small-RNA-mediated transposon control.Trends in cell biology · 2008Review
- Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements.PLoS genetics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plethora of genomic information gathered by the sequencing of the human and mouse genomes has paved the way for a new era of genetics. While in the past we focused mainly on the small percentage of DNA that codes for proteins, we can now concentrate on the remainder, i.e. the noncoding sequences that interrupt and separate genes. This portion of the genome is made up, in most part, of repetitive DNA sequences including DNA transposons, long terminal repeat (LTR) retrotransposons, LINEs (long interspersed nuclear elements) and SINEs (short interspersed nuclear elements). Some of these elements are transcriptionally active and can transpose or retrotranspose around the genome, resulting in insertional mutagenesis that can cause disease. In these cases, insertions have occurred in the coding sequence. However, recent evidence suggests that the main effect of these elements is their ability to influence transcription of neighbouring genes. The elements themselves contain promoters that can initiate transcription of flanking genomic DNA. Furthermore, they are susceptible to epigenetic silencing, which is often stochastic and incomplete, resulting in complex patterns of transcription. This review discusses some diseases in both human and mouse that are caused by these repetitive elements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.