ArticleEukaryotic cell2004
The Gbeta-subunit-encoding gene bpp1 controls cyclic-AMP signaling in Ustilago maydis.
Article in Eukaryotic cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- A co-evolved peptide-GPCR system senses host entry to drive fungal infection.Nature communications · 2026Article
- Ustilago maydis PR-1-like protein has evolved two distinct domains for dual virulence activities.Nature communications · 2023Article
- Research on the Molecular Interaction Mechanism between Plants and Pathogenic Fungi.International journal of molecular sciences · 2022Review
- Article
- Investigating the Smuts: Common Cues, Signaling Pathways, and the Role ofJournal of fungi (Basel, Switzerland) · 2020Review
- Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication.Current biology : CB · 2016Article
- The cAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis.Journal of microbiology (Seoul, Korea) · 2015Review
- Cloning and functional analysis of the Gβ gene Mgb1 and the Gγ gene Mgg1 in Monascus ruber.Journal of microbiology (Seoul, Korea) · 2014Article
- Overview of the functional virulent genome of the coffee leaf rust pathogen Hemileia vastatrix with an emphasis on early stages of infection.Frontiers in plant science · 2014Article
- The late endosomal HOPS complex anchors active G-protein signaling essential for pathogenesis in magnaporthe oryzae.PLoS pathogens · 2013Article
- Regulators of G-protein signalling in Fusarium verticillioides mediate differential host-pathogen responses on nonviable versus viable maize kernels.Molecular plant pathology · 2011Article
- The Ustilago maydis Clp1 protein orchestrates pheromone and b-dependent signaling pathways to coordinate the cell cycle and pathogenic development.The Plant cell · 2010Article
- Basidiomycete mating type genes and pheromone signaling.Eukaryotic cell · 2010Review
- G(alpha) and Gbeta proteins regulate the cyclic AMP pathway that is required for development and pathogenicity of the phytopathogen Mycosphaerella graminicola.Eukaryotic cell · 2009Article
- Functional analyses of heterotrimeric G protein G alpha and G beta subunits in Gibberella zeae.Microbiology (Reading, England) · 2008Article
- Mitogen-activated protein kinase pathways and fungal pathogenesis.Eukaryotic cell · 2007Review
- The cAMP pathway is important for controlling the morphological switch to the pathogenic yeast form of Paracoccidioides brasiliensis.Molecular microbiology · 2007Article
- Multiple roles of a heterotrimeric G-protein gamma-subunit in governing growth and development of Aspergillus nidulans.Genetics · 2005Article
- Ustilago maydis: how its biology relates to pathogenic development.The New phytologist · 2004Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the phytopathogenic fungus Ustilago maydis, fusion of haploid cells is a prerequisite for infection. This process is controlled by a pheromone-receptor system. The receptors belong to the seven-transmembrane class that are coupled to heterotrimeric G proteins. Of four Galpha subunits in U. maydis, only gpa3 has a function during mating and cyclic AMP (cAMP) signaling. Activation of the cAMP cascade induces pheromone gene expression; however, it does not lead to the induction of conjugation tubes seen after pheromone stimulation. To investigate the possibility that a Gbeta subunit participates in pheromone signaling, we isolated the single beta subunit gene, bpp1, from U. maydis. bpp1 deletion mutants grew filamentously and showed attenuated pheromone gene expression, phenotypes associated with deltagpa3 strains. In addition, a constitutively active allele of gpa3 suppressed the phenotype of the bpp1 deletion strains. We suggest that Bpp1 and Gpa3 are components of the same heterotrimeric G protein acting on adenylyl cyclase. Interestingly, while deltagpa3 strains are impaired in pathogenicity, deltabpp1 mutants are able to induce plant tumors. This could indicate that Gpa3 operates independently of Bpp1 during pathogenic development.
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